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College Football Week 10 Opening Lines

The Florida State Seminoles remain at No. 2 in the AP Top 25 for this week, and they'll kick off the Week 10 college football schedule on Thursday night as 6.5-point road favorites on the opening betting lines at the online sportsbooks against the Louisville Cardinals.

Florida State is 7-0 SU but just 1-6 ATS on the season, and they're 4-8 ATS in their last dozen games as favorites on the road according to the college football betting trends for this week. Louisville will enter Thursday night's game at 6-2 SU and 5-3 ATS on the season, and they're 6-2 ATS in their last eight home games against fellow ACC teams.

Matchup Reports: Florida State vs. Louisville | Arizona vs. UCLA | Utah vs. Arizona State

There are four games between ranked teams on the college football betting slate for Week 10, and the biggest has No. 7 Ole Miss as a 3-point favorite on the opening odds against No. 7 Auburn. As well, No. 10 TCU opened as a 5.5-point road favorite against No. 20 West Virginia.

The other two ranked matchups for this week are out in the Pac-12, with No. 25 UCLA opening as a 5-point home favorite against No. 14 Arizona, and No. 15 Arizona State opening as a 4.5-point home favorite against No. 18 Utah. No. 5 Oregon opened as an 11.5-point home favorite against unranked Stanford for their matchup on Saturday.

Elsewhere, top-ranked Mississippi State opened as an 11.5-point home favorite against Arkansas, while No. 9 Georgia opened as a 13-point favorite against Florida for their game at EverBank Field, and No. 6 Notre Dame opened as a 15-point favorite on the road against Navy. The Fighting Irish are 4-1 ATS in their last five games against the Midshipmen.

College Football Week 10 Opening Betting Lines at 5Dimes (Posted As Available)

THURSDAY, OCTOBER 30
7:30pm ET - Florida State at Louisville (+6.5)
7:30pm ET - Troy at Georgia Southern (-24)

FRIDAY, OCTOBER 31
8:00pm ET - Cincinnati at Tulane (+3.5)
8:00pm ET - Tulsa at Memphis (-22)

SATURDAY, NOVEMBER 1
11:30pm ET - Air Force at Army (+4)
12:00pm ET - Oklahoma at Iowa State (+15.5)
12:00pm ET - UCF at Connecticut (+11.5)
12:00pm ET - Maryland at Penn State (-3)
12:00pm ET - Northwestern at Iowa (-5.5)
12:00pm ET - East Carolina at Temple (+7.5)
12:00pm ET - Wisconsin at Rutgers ()
12:00pm ET - Rice at Florida International (+7)
12:00pm ET - Duke at Pittsburgh (-1)
12:00pm ET - Louisiana-Monroe at Texas A&M (-32)
12:30pm ET - Boston College at Virginia Tech (-5.5)
12:30pm ET - North Carolina at Miami (-12)
1:00pm ET - Washington at Colorado (+5.5)
1:00pm ET - Central Michigan at Eastern Michigan (+16.5)
2:30pm ET - Western Michigan at Miami-Ohio (+6)
3:00pm ET - Western Kentucky at Louisiana Tech (-5)
3:00pm ET - North Carolina State at Syracuse (-5)
3:30pm ET - Purdue at Nebraska (-23.5)
3:30pm ET - TCU at West Virginia (+5.5)
3:30pm ET - Florida vs. Georgia (-13) (EverBank Field)
3:30pm ET - BYU at Middle Tennessee (+7)
3:30pm ET - Indiana at Michigan (-8.5)
3:30pm ET - Virginia at Georgia Tech (-4)
3:30pm ET - Georgia State at Appalachian State (-6.5)
4:00pm ET - Kansas at Baylor (-35)
4:00pm ET - Kentucky at Missouri (-6.5)
4:00pm ET - Texas State at New Mexico State (+8.5)
4:00pm ET - Houston at South Florida (+9.5)
4:30pm ET - USC at Washington State (+7.5)
5:00pm ET - Arkansas State at Idaho ()
5:00pm ET - South Alabama at Louisiana-Lafayette (-7)
5:30pm ET - New Mexico at UNLV (-1)
7:00pm ET - Auburn at Ole Miss (-3)
7:00pm ET - Colorado State at San Jose State (+7)
7:00pm ET - Old Dominion at Vanderbilt (-10)
7:00pm ET - UAB at Florida Atlantic ()
7:15pm ET - Arkansas at Mississippi State (-11.5)
7:30pm ET - Stanford at Oregon (-11.5)
7:30pm ET - Texas at Texas Tech ()
7:30pm ET - Tennessee at South Carolina (-8)
8:00pm ET - Oklahoma State at Kansas State (-13)
8:00pm ET - Notre Dame at Navy (+15)
8:00pm ET - Illinois at Ohio State (-28.5)
8:00pm ET - Southern Miss at UTEP (-5.5)
10:30pm ET - California at Oregon State (-4.5)
10:30pm ET - Arizona at UCLA (-5)
10:30pm ET - San Diego State at Nevada (-5)
10:45pm ET - Wyoming at Fresno State (-11)
11:00pm ET - Utah State at Hawaii (+2)
11:00pm ET - Utah at Arizona State (-4.5)

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