Louisville Cardinals - NCAAF Schedule for 2025
| Date | Opponent | Game | Result | Score | ATS | Spread | OU | Total |
|---|---|---|---|---|---|---|---|---|
| Aug 30, 2025 | vs Eastern Kentucky | REG | W | 51-17 | L | -38.5 | O | 56.5 |
| Sep 5, 2025 | vs James Madison | REG | W | 28-14 | L | -14.5 | U | 56.5 |
| Sep 20, 2025 | vs Bowling Green | REG | W | 40-17 | L | -26.5 | O | 51 |
| Sep 27, 2025 | @ Pittsburgh | REG | W | 34-27 | W | -3 | O | 54.5 |
| Oct 4, 2025 | vs Virginia | REG | L | 30-27 | L | -6.5 | U | 60 |
| Oct 17, 2025 | @ Miami-FL | REG | W | 24-21 | W | +10.5 | U | 49.5 |
| Oct 25, 2025 | vs Boston College | REG | W | 38-24 | L | -25.5 | O | 54.5 |
| Nov 1, 2025 | @ Virginia Tech | REG | W | 28-16 | W | -10.5 | U | 52.5 |
| Nov 8, 2025 | vs California | REG | L | 29-26 | L | -18.5 | O | 49.5 |
| Nov 14, 2025 | vs Clemson | REG | L | 20-19 | L | -1.5 | U | 50.5 |
| Nov 22, 2025 | @ Southern Methodist | REG | L | 38-6 | L | +3.5 | U | 49.5 |
| Nov 29, 2025 | vs Kentucky | REG | W | 41-0 | W | -1.5 | U | 45.5 |
| Dec 23, 2025 | vs Toledo | PST |
