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Novak Djokovic leads the 2021 US Open Tennis Odds.

Nearing the end of the 2021 tennis season, there are still some results that have yet to be decided. Here is a look at who the favorites are as we approach the quarterfinals of the 2021 Men’s U.S. Open.

According to the best tennis betting sites, Novak Djokovic is now the -165 favorite as we wrap up the round of 16 of the U.S. Open. Djokovic is followed by the No. 2-ranked Daniil Medvedev (+185) and the No. 4-ranked Alexander Zverev (+500). After these guys, there is a massive drop-off in odds as Carlos Alcaraz Garfia (+2500) and Matteo Berrettini (+3000) close out our top five. 

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Who Are The 2021 U.S. Open Betting Favorites?

Odds To Win 2021 U.S. Open - Men’s
Player Odds
Novak Djokovic -165
Daniil Medvedev +185
Alexander Zverev +500
Carlos Alcaraz Garfia +2500
Matteo Berrettini +3000
Felix Auger-Aliassime +3300
Jannik Sinner +6000
Reilly Opelka +8000
Jenson Brooksby +12500
Lloyd Harris +20000
Botic van de Zandschulp +35000
Oscar Otte +35000

Odds as of September 6 at [ol-sportsbook-bp:48:Bovada:26:Bodog]

Novak Djokovic Path To A Calendar Grand Slam

World No. 1 Novak Djokovic continues to make a case for being the greatest player of all time. Djokovic is having a year for the ages, already winning the three other major tournaments, and cannot be stopped right now, en route to an elusive Grand Slam (winning all four major tournaments).

Djokovic began his tournament with a four-set win over an unranked Holger Rune. He then went on to beat another unranked player, Tallon Griekspoor, in straight sets in the second round.

He faced a much tougher challenge in round 3, playing a former top-10 player in Kei Nishikori. Djokovic lost the first set but stayed composed and won the next three sets to book a trip to the round of 16.

He will face the 99th-ranked Jenson Brooksby in his round of 16 matchup. Novak should cruise to another victory and book a trip to the quarterfinals.

Looking at the rest of the bracket, Djokovic will likely play the No. 6 player in the world, Matteo Berrettini, in the quarterfinals. After that, he could play No. 4 Alexander Zverev before finally facing Daniil Medvedev, the second-ranked player in the world. These are all hypothetical matchups, but it appears that a finals matchup between Djokovic and Medvedev is increasingly likely.

Can Anyone Beat Djokovic?

Looking at the U.S. Open tennis odds, Daniil Medvedev (+185) and Alexander Zverev (+500) are closest to Djokovic on the oddsboard.

Daniil Medvedev

This would be Djokovic and Medvedev’s ninth head-to-head matchup, with Djokovic winning five of eight thus far. Two of those matchups came in major tournaments with the last one coming in the finals of this year’s Australian Open, when Djokovic beat Medvedev in straight sets to win the championship.

If these two are to play each other once again, it would be in another major final. This is a matchup that many fans are hoping for and expecting to happen.

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Alexander Zverev

For Zverev, this would be his 10th head-to-head matchup with Djokovic, with Djokovic leading the series 6-3.

Their most recent match was in the Tokyo Olympics where Zverev shocked many people in beating the No. 1 player in the world in three sets. Their last match at a major was in this year’s Australian Open quarterfinals where Djokovic won a tight four-setter that included two tiebreaks.

If these two are to play each other for the 10th time, it would be in the semifinals, and is another matchup that seems increasingly likely to happen. Zverev provides a credible challenge for Novak, but Djokovic is playing on another level right now.

Best Bet: Novak Djokovic (-165)

Who Are The 2021 U.S. Open Betting Favorites?

Odds To Win 2021 U.S. Open - Women’s
Player Odds
Aryna Sabalenka +110
Karolina Pliskova +500
Belinda Bencic +550
Leylah Annie Fernandez +550
Emma Raducanu +800
Maria Sakkari +900

Sabalenka’s Path To The Semifinals

Aryna Sabalenka, the No. 2-ranked player in the world, has put on masterclass performances booking her way into the semifinals.

Thus far, Sabalenka has lost one set the entire tournament, with that set coming in the first round when she lost in a tiebreak to Nina Stojanovic. From that point on, Sabalenka has defeated Tamara Zidansek, No. 26-ranked Danielle Collins and No. 16 Elise Mertens, all in straight sets. 

Can Leylah Fernandez beat Sabalenka?

Looking ahead to the semifinals, Sabalenka will face off against Canadian youngster Leylah Fernandez. Fernandez has had a spectacular tournament thus far, reaching her first career Grand Slam semifinal at the age of just 19.

Fernandez’s path to this point has been much more difficult than Sabalenka’s. She has had to beat Naomi Osaka, the No. 3 player in the world, and Angelique Kerber, the 17th-ranked player in the world. Not to mention her matchup in the Round of 16, which was decided in a third-set tiebreak.

Fernandez comes into this semifinal matchup as a +320 underdog ($100 to win $320). Both of these players have been playing phenomenal tennis.

I would give the edge to Sabalenka because she made it to the semifinals at Wimbledon, so she has the experience factor. But I think there is a ton of value on Fernandez at +320.

Who Is The Biggest Threat To Sabalenka?

Fernandez and Sabalenka have already booked their ticket to the semis, but the remaining players still have some work to do.

Karolina Pliskova

No. 4-ranked Karolina Pliskova has had one scare, in her second-round matchup. But other than that, she has been absolutely flawless, winning each of her other matches in straight sets.

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Pliskova is set to face the 17 seed, Maria Sakkari, in a matchup in which both players have won in their two head-to-head matches. The odds show that this matchup is going to be a close one with Pliskova pegged as the slight favorite at -135.

Belinda Bencic

Another player playing outstanding tennis is 11th-ranked Belinda Bencic. Bencic has also cruised, not losing a single set thus far.

Bencic is set to face unranked Emma Raducanu. Raducanu is currently undefeated in her last 12 matches on hardcourt, so she is certainly not going to be an easy out. This will be the first head-to-head meeting between the two.

Bencic is playing great tennis, however, I believe she is going to have a difficult time if she has to face Pliskova or Sabalenka. I think that Sabalenka and Pliskova are on a collision course to meet in this year’s finals.

Best Bet: Aryna Sabalenka (+110) to Win U.S. Open