Duke Blue Devils - NCAAF Schedule for 2025
| Date | Opponent | Game | Result | Score | ATS | Spread | OU | Total |
|---|---|---|---|---|---|---|---|---|
| Aug 28, 2025 | vs Elon | REG | W | 45-17 | L | -36.5 | O | 51.5 |
| Sep 6, 2025 | vs Illinois | REG | L | 45-19 | L | +2.5 | O | 48.5 |
| Sep 13, 2025 | @ Tulane | REG | L | 34-27 | L | +1.5 | O | 52.5 |
| Sep 20, 2025 | vs North Carolina State | REG | W | 45-33 | W | -3 | O | 56.5 |
| Sep 27, 2025 | @ Syracuse | REG | W | 38-3 | W | -4 | U | 59.5 |
| Oct 4, 2025 | @ California | REG | W | 45-21 | W | -3.5 | O | 54.5 |
| Oct 18, 2025 | vs Georgia Tech | REG | L | 27-18 | L | -3.5 | U | 60.5 |
| Nov 1, 2025 | @ Clemson | REG | W | 46-45 | W | +3.5 | O | 54.5 |
| Nov 8, 2025 | @ Connecticut | REG | L | 37-34 | L | -7.5 | O | 63.5 |
| Nov 15, 2025 | vs Virginia | REG | L | 34-17 | L | -5 | U | 59.5 |
| Nov 22, 2025 | @ North Carolina | REG | W | 32-25 | P | -7 | O | 50.5 |
| Nov 29, 2025 | vs Wake Forest | REG | W | 49-32 | W | -2.5 | O | 53.5 |
| Dec 6, 2025 | @ Virginia | REG | W | 27-20 | W | +3.5 | U | 58.5 |
| Dec 31, 2025 | vs Arizona State | PST |
