| Date | Opponent | Game | Result | Score | ATS | Spread | OU | Total |
|---|---|---|---|---|---|---|---|---|
| Sep 4, 2021 | @ Maryland | REG | ||||||
| Sep 11, 2021 | vs LIU | REG | ||||||
| Sep 18, 2021 | vs Virginia Tech | REG | ||||||
| Sep 25, 2021 | @ Oklahoma | REG | ||||||
| Oct 2, 2021 | vs Texas Tech | REG | ||||||
| Oct 9, 2021 | @ Baylor | REG | ||||||
| Oct 23, 2021 | @ Texas Christian | REG | ||||||
| Oct 30, 2021 | vs Iowa State | REG | ||||||
| Nov 6, 2021 | vs Oklahoma State | REG | ||||||
| Nov 13, 2021 | @ Kansas State | REG | ||||||
| Nov 20, 2021 | vs Texas | REG | ||||||
| Nov 27, 2021 | @ Kansas | REG |
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