Iowa State Cyclones - NCAAF Schedule for 2022
| Date | Opponent | Game | Result | Score | ATS | Spread | OU | Total |
|---|---|---|---|---|---|---|---|---|
| Sep 3, 2022 | vs Southeast Missouri State | REG | W | 42-10 | L | -33.5 | U | 54.5 |
| Sep 10, 2022 | @ Iowa | REG | W | 10-7 | W | +3.5 | U | 39 |
| Sep 17, 2022 | vs Ohio | REG | W | 43-10 | W | -20 | O | 48 |
| Sep 24, 2022 | vs Baylor | REG | L | 31-24 | L | -2.5 | O | 45 |
| Oct 1, 2022 | @ Kansas | REG | L | 14-11 | L | -3.5 | U | 59 |
| Oct 8, 2022 | vs Kansas State | REG | L | 10-9 | P | +1 | U | 45 |
| Oct 15, 2022 | @ Texas | REG | L | 24-21 | W | +15.5 | U | 48.5 |
| Oct 29, 2022 | vs Oklahoma | REG | L | 27-13 | L | +1.5 | U | 58 |
| Nov 5, 2022 | vs West Virginia | REG | W | 31-14 | W | -6.5 | U | 49.5 |
| Nov 12, 2022 | @ Oklahoma State | REG | L | 20-14 | L | -2.5 | U | 47.5 |
| Nov 19, 2022 | vs Texas Tech | REG | L | 14-10 | L | -3.5 | U | 47.5 |
| Nov 26, 2022 | @ Texas Christian | REG | L | 62-14 | L | +9.5 | O | 45.5 |
