Best NFL Prop Bets Week 15

Today

Jerry Jeudy O36.5 Receiving Yards
NFL | CLE @ CHI 1:00 PM ET
FanDuel Sportsbook logo
-114
Patrick Mahomes O1.5 Passing Touchdowns
NFL | LAC @ KC 1:00 PM ET
FanDuel Sportsbook logo
+112
Chase Brown Touchdown Scorer
NFL | BAL @ CIN 1:00 PM ET
DraftKings Sportsbook logo
+155
Derrick Henry OVER 91.5 Rushing Yards
NFL | BAL @ CIN 1:00 PM ET
FanDuel Sportsbook logo
-110
TreVeyon Henderson O45.5 Rushing Yards
NFL | BUF @ NE 1:00 PM ET
FanDuel Sportsbook logo
-114
Gabe Davis Anytime TD
NFL | BUF @ NE 1:00 PM ET
bet365 Sportsbook logo
+480
Jameson Williams Anytime TD
NFL | DET @ LAR 4:25 PM ET
FanDuel Sportsbook logo
+175
Ricky Pearsall O35.5 Receiving Yards
NFL | TEN @ SF 4:25 PM ET
FanDuel Sportsbook logo
-114
Jordan Love U223.5 Passing Yards
NFL | GB @ DEN 4:25 PM ET
DraftKings Sportsbook logo
-111
Justin Jefferson Anytime TD
NFL | MIN @ DAL 8:20 PM ET
FanDuel Sportsbook logo
+170
Justin Jefferson O59.5 Rec Yards
NFL | MIN @ DAL 8:20 PM ET
DraftKings Sportsbook logo
-108
Tomorrow

Jaylen Warren U13.5 Rec Yards
NFL | MIA @ PIT 8:15 PM ET
BetMGM Sportsbook logo
-110
Jaylen Waddle O61.5 Receiving Yards
NFL | MIA @ PIT 8:15 PM ET
FanDuel Sportsbook logo
-114
De’Von Achane U16.5 Carries
NFL | MIA @ PIT 8:15 PM ET
FanDuel Sportsbook logo
-102
Thursday

Rachaad White UNDER 1.5 Receptions
NFL | ATL @ TB 8:15 PM ET
BetMGM Sportsbook logo
+100
Falcons 2H Points U9.5
NFL | ATL @ TB 8:15 PM ET
DraftKings Sportsbook logo
+100
Baker Mayfield 1+ Interception
NFL | ATL @ TB 8:15 PM ET
FanDuel Sportsbook logo
+106

Sunday Football Prop Picks

Jerry Jeudy OVER 36.5 Receiving yards (-114)

Jeudy is set up to go well over that total. The Bears have given up the 13th-most receiving yards to wideouts this season (plus the third-most touchdowns), and Jeudy is fresh off one of his best outings of the season. The veteran appears to be developing solid chemistry with Shedeur Sanders, and that should be enough to net Jeudy over 36.5 yards Sunday. - Andrew Dixon


TreVeyon Henderson OVER 45.5 Rushing Yards (-114)

Henderson has gone over this total in six straight games, with his lowest output in that window being 55 yards. He's earned at least 10 carries in all of those contests, and should get a similar workload against the Bills. Buffalo is one of the worst teams in the NFL at defending tailbacks, giving up 108.8 rushing yards per game to running backs. Only five teams have given up more.  - Andrew Dixon


Jameson Williams Anytime TD (+175)

Williams has recorded at least 66 receiving yards in six of his last eight games, and he's scored a touchdown in five of those games. He's also seen at least six targets in six of those eight and should continue to be involved against the Rams. His all-world speed could be a difference maker, and I expect it to get him in the end zone with his solid volume. The Rams have only given up 11 receiving touchdowns to wideouts, but they've allowed just nine to running backs and tight ends combined, so I'm riding with Williams and his solid +175 value. - Andrew Dixon


Ricky Pearsall OVER 35.5 Receiving yards (-114)

The Titans have allowed the sixth-most receiving yards to wideouts this season. Pearsall has been banged up and inconsistent this season, but this is his best opportunity to show out that he's had since returning from injury. The 25-year-old posted at least 46 yards in all four games to start the season before missing time, so this game is a perfect opportunity to round back into form. - Andrew Dixon 


Derrick Henry OVER 91.5 Rushing Yards (-110)

Derrick Henry draws a dream matchup against Cincinnati’s league-worst run defense, which is allowing 160.9 rushing yards per game and routinely struggles to contain physical backs. With Baltimore expected to lean heavily on the ground game in a competitive script, Henry’s workload and efficiency make the over a strong value at 91.5 yards. - Ethan Diamandas


Jordan Love UNDER 223.5 Passing Yards (-111)

Love has failed to exceed 223.5 passing yards in five straight games versus top-10 defenses for passing yards allowed, averaging 181 yards per game. He failed to throw for even 200 yards against the Vikings and Browns this season, and faces a tough test against a Broncos defense surrendering just 193 passing yards per game. -Nick Holz


Justin Jefferson Anytime TD (+170)

No team has given up more receiving touchdowns to wideouts than the Cowboys have (22). That should help Jefferson score just his third touchdown of the season. The Vikings looked better than they have lately last week against the Commanders, but Jefferson was still held in check. I expect Minnesota to aggressively target its two-time First-Team All-Pro against a vulnerable defense on Sunday Night Football. - Andrew Dixon

Justin Jefferson OVER 59.5 Receiving Yards (-108)

Sunday Night Football is the perfect spot for Justin Jefferson to bounce back. He's averaged close to eight targets a night and has crossed this line in three games with McCarthy under center. Expect to see Jefferson targeted early and often against a Cowboys team surrendering the most yards to wide receivers (171) per game. -Nick Holz


Chase Brown Anytime TD (+155)

Brown is a bargain to find the endzone at +155 in a game with a high total. Brown has 15+ touches in six straight games, and scored twice last week in Buffalo. 

He's Joe Burrow's safety valve, and with the Bengals scoring 35 points per game since Burrow's return, Brown should have a ton of opportunities to score in Week 15. The Canadian is Cincinnati's lead back and has 29 redzone touches this season. -Nick Holz


Gabe Davis Anytime TD (+480)

Davis has a ton of redzone rapport with Josh Allen, having been on the receiving end of 27 total touchdowns in four years with the Bills. He's seen three redzone targets in just four games this season, and is a reat bet to score in a Pats vs Bills game that profiles as a shootout. With New England focused on stopping the run and taking away Dalton Kincaid - and Keon Coleman in the dog house - the big-bodied Davis is the Bills outside threat in the endzone. -Nick Holz

Patrick Mahomes OVER 1.5 Passing Touchdowns (+112)

Expect the Chiefs to put the game in Mahomes' hands with their season on the line. The two-time NFL MVP has torched the Chargers to the tune of 271 passing yards and 2.2 touchdowns per game with a 100.1 passer rating in 13 games during his career. He's also averaged nearly six redzone attempts per game this season with a 91.6 passer rating in the red area. Back Mahomes o play his best football on Sunday with his team's back against the wall. -Nick Holz


Monday Night Football Prop Picks

De'Von Achane UNDER 16.5 Carries

Achane may not even suit up this week, which would result in this bet being voided. If he does play, I can't imagine the Dolphins giving him 17 or more carries because of the injury to his ribs that forced him out of Miami's last game against the Jets. That's especially true because of how well Jaylen Wright filled in for Achane. The Tennessee product had 107 yards and a touchdown on 24 carries after taking over. - Andrew Dixon


Jaylen Waddle OVER 61.5 Receiving Yards

The Steelers have conceded the second-most receiving yards to wide receivers this season, and Waddle has been a consistent part of the Miami offense. He's fallen shy of 61.5 in his last three games, but he cleared it with ease in his previous three. I like him to take advantage of this matchup on Monday Night Football. - Andrew Dixon

Jaylen Warren UNDER 13.5 Receiving Yards

Jaylen Warren has failed to exceed 13.5 receiving yards in five straight homes games. Kenneth Gainwell has taken over as the Steelers receiving back, and Warren has seen only 11 targets over the past five weeks. The Dolphins give up just 4.5 receptions per game to opposing backs, so don't expect to see much of Warren in the passing game on Monday Night Football. He's crossed 13.5 receiving yards just three times in the past nine games. -Nick Holz


Thursday Night Football Prop Picks 

Baker Mayfield 1+ Interception (+160)

The Falcons have forced an interception in two of their last three and four of their last six. They've tallied 10 on the season, which is tied for the twelfth most in the league. Mayfield has also tossed at least one pick in three of his last four games. I'm already expecting the game to cash its under, and a pick from Mayfield could wind up helping that out by limiting Tampa Bay's scoring opportunities. - Andrew Dixon


Falcons 2H Points UNDER 9.5 (+100)

The Falcons have failed to hit 10 second-half points in seven of their last 10 games while averaging 8.8 per contest. 

Among quarterbacks to take over 100 snaps this season, Kirk Cousins ranks 39th in EPA per play with just a 44% success rate. The Falcons are a brutal 31st in third-down conversion percentage, and are averaging just 19.4 total points per game. -Nick Holz


Prop Professor EV Bet: Rachaad White UNDER 1.5 Receptions (+100)

According to Prop Professor's projections, Rachaad White's reception market is in a good spot at BetMGM, showing a +1.6% expected value edge. White's pass-catching role has significantly diminished in recent weeks, as he's been held to two catches and 11 yards or fewer in three of the last four games. White caught just one reception in Week 14 against the Saints on two targets, and his receiving opportunities have dwindled in Tampa Bay's three-back rotation with Irving and Sean Tucker.

These +EV opportunities come and go at a moment's notice, but if you are looking for more insights like this, try out Prop Professor today and get 50% off your first month with promo code: ODDSSHARK50.

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There's no better time to plunge into the world of NFL prop bets. Unlike traditional wagers like the point spread and moneyline, NFL prop bets allow you to focus on player performances and specific game scenarios, offering a ton of opportunities for bettors to capitalize on their intimate knowledge of the game. Whether you're betting on a quarterback's passing yards, a running back to score a touchdown, or a wide receiver's receptions, player props provide endless ways to enhance your betting experience.

With the 2025 NFL season in full swing, Odds Shark's NFL experts Nick Holz and Andrew Dixon will break down their best NFL prop bets weekly.

Check out all of our best NFL prop bets throughout the season and all the way to the Super Bowl!

2025-2026  NFL Prop Picks Results
ExpertRecordUnits
Nick Holz26-37-1-8.2
Tony Farmer7-14-2.59
Andrew Dixon4-5+0.65
Overall37-57-1-10.14

We finished last season up a total of +5.31 units, so be sure to stay locked in on our 2025 NFL prop picks!

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