Michigan State Spartans - NCAAF Schedule for 2025
| Date | Opponent | Game | Result | Score | ATS | Spread | OU | Total |
|---|---|---|---|---|---|---|---|---|
| Aug 29, 2025 | vs Western Michigan | REG | W | 23-6 | L | -21.5 | U | 49.5 |
| Sep 6, 2025 | vs Boston College | REG | W | 42-40 | L | -3.5 | O | 45.5 |
| Sep 13, 2025 | vs Youngstown State | REG | W | 41-24 | L | -24 | O | 55.5 |
| Sep 20, 2025 | @ Southern California | REG | L | 45-31 | W | +18.5 | O | 55.5 |
| Oct 4, 2025 | @ Nebraska | REG | L | 38-27 | W | +13 | O | 48.5 |
| Oct 11, 2025 | vs California-Los Angeles | REG | L | 38-13 | L | -7 | U | 51.5 |
| Oct 18, 2025 | @ Indiana | REG | L | 38-13 | W | +26.5 | O | 49.5 |
| Oct 25, 2025 | vs Michigan | REG | L | 31-20 | W | +13.5 | O | 47.5 |
| Nov 1, 2025 | @ Minnesota | REG | L | 23-20 | W | +4.5 | U | 44.5 |
| Nov 15, 2025 | vs Penn State | REG | L | 28-10 | L | +7 | U | 48.5 |
| Nov 22, 2025 | @ Iowa | REG | L | 20-17 | W | +17.5 | U | 42.5 |
| Nov 29, 2025 | vs Maryland | REG | W | 38-28 | W | -4 | O | 49.5 |
