Week 5 of the 2025 college football season features a heavyweight matchup between No. 4 LSU and No. 13 Ole Miss at Vaught–Hemingway Stadium in Mississippi. The Rebels are 2.5-point favorites despite being the lower-ranked team, and the total is set at 55.5 points at FanDuel. Both teams enter the contest at 4-0, though Ole Miss has played two SEC games compared to LSU's one.
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LSU vs Ole Miss Odds
Matchup Page: LSU vs Ole Miss, Sept 27, 3:30 pm ET
| Team | Spread | Moneyline | Total |
|---|---|---|---|
| LSU Tigers | +2.5 (-112) | +112 | OVER 57.5 (-110) |
| Ole Miss Rebels | -2.5 (-108) | -134 | UNDER 57.5 (-110) |
Odds as of September 27, 2025 at FanDuel
LSU vs Ole Miss pick
These two programs are known for their offensive production, and that doesn't change when they face one another. LSU and Ole Miss have combined to go over the game's opening total of 55.5 points in seven of their last 10 meetings with one another. The only matchups that finished with under 55.5 total points in that time are a 29-26 (55) LSU win last season, a 31-17 (48) Ole Miss victory in 2021, and a 38-17 (55) win for the Rebels in 2015. And the programs didn't narrowly go over 55.5 points in the seven matchups that did hit that total. The average combined score of those games was 78.4, with two games over 100 and another over 90.
It's important to evaluate their numbers this season in addition to the historical data. LSU's competition has been more talented, with wins over Clemson and Florida among their 2025 victories, and the Tigers are averaging 29 points and 391.8 yards per game. Ole Miss, on the other hand, has put up 44.8 points and 543.2 yards per game, ranking 12th and ninth in the nation, respectively. Ole Miss should also benefit from playing at home, as they've scored at least 41 points in every home game this season.
There's a chance the total comes down to the wire, but recent and historical numbers show these two SEC powerhouses could hit the over with plenty of time to spare.
LSU vs Ole Miss Pick: OVER 55.5 (-110)
*Pick made Sept. 22 before line movement
LSU vs Ole Miss Prop Bet
LSU WR Barion Brown Anytime TD: +155
Brown should see plenty of targets in this one. The 21-year-old has almost matched his reception total from last year with Kentucky (29), hauling in 20 receptions through four games. He's found the end zone once this season and should have another chance in what I expect to be a high-scoring game.
LSU vs Ole Miss Betting Trends
- The total has gone OVER in 7 of LSU's last 10 road games against Ole Miss
- The total has gone OVER in four of Ole Miss' last five games
- Ole Miss RB Kewan Lacy has scored at least one rushing touchdown in every game this season
