Penn State Nittany Lions - NCAAF Schedule for 2025
| Date | Opponent | Game | Result | Score | ATS | Spread | OU | Total |
|---|---|---|---|---|---|---|---|---|
| Aug 30, 2025 | vs Nevada | REG | W | 46-11 | L | -42.5 | O | 54.5 |
| Sep 6, 2025 | vs Florida International | REG | W | 34-0 | L | -42 | U | 53.5 |
| Sep 13, 2025 | vs Villanova | REG | W | 52-6 | L | -47.5 | O | 56.5 |
| Sep 27, 2025 | vs Oregon | REG | L | 30-24 | L | -4 | O | 52.5 |
| Oct 4, 2025 | @ California-Los Angeles | REG | L | 42-37 | L | -24.5 | O | 48.5 |
| Oct 11, 2025 | vs Northwestern | REG | L | 22-21 | L | -20.5 | U | 46.5 |
| Oct 18, 2025 | @ Iowa | REG | L | 25-24 | W | +3 | O | 41.5 |
| Nov 1, 2025 | @ Ohio State | REG | L | 38-14 | L | +17.5 | O | 45 |
| Nov 8, 2025 | vs Indiana | REG | L | 27-24 | W | +13.5 | O | 50.5 |
| Nov 15, 2025 | @ Michigan State | REG | W | 28-10 | W | -7 | U | 48.5 |
| Nov 22, 2025 | vs Nebraska | REG | W | 37-10 | W | -7 | O | 45.5 |
| Nov 29, 2025 | @ Rutgers | REG | W | 40-36 | L | -14 | O | 55.5 |
| Dec 27, 2025 | @ Clemson | PST | W | 22-10 | W | +2.5 | U | 48 |
