No. 2 Indiana and No. 1 Ohio State meet in Indianapolis with matching 12-0 SU records in the highly anticipated Big Ten Championship. However, the betting market still gives the Buckeyes the edge as 4.5-point favorites at FanDuel, with the total hovering around 47.5. Everything is on the line: the Big Ten crown, the No. 1 seed in the College Football Playoff and a Heisman showdown between two of the nation's strongest quarterbacks.
indiana vs ohio state Odds
Matchup Page: Indiana vs Ohio State, Dec. 6, 8 pm ET
| Team | Spread | Moneyline | Total |
|---|---|---|---|
| Indiana Hoosiers | +4.5 (-115) | +160 | OVER 47.5 (-110) |
| Ohio State Buckeyes | -4.5 (-105) | -190 | UNDER 47.5 (-110) |
Odds as of December 6th, 2025 at FanDuel
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indiana vs ohio state Pick
Indiana’s (7-5 ATS) electric offense is the main reason this spread isn’t bigger. Heisman-favorite Fernando Mendoza has been one of the hottest QBs in the country, racking up 2,758 passing yards, 32 touchdowns, and just a handful of turnovers (5), plus another six rushing scores. He’s supported by a ground game led by Roman Hemby (866 yards, 6 TDs) and one of the best receiver duos in college football: Omar Cooper Jr. (840 yards, 11 TDs) and Elijah Sarratt (650 yards, 11 TDs). Indiana ranks third in offensive touchdowns per game (5.1), showing its a threat each drive.
Ohio State (10-1-1 ATS) counters with its defense. The Buckeyes haven’t allowed more than 16 points all season and only four teams have even reached double digits against them. The Buckeyes secondary generates a ton of pressure, recording 2.5 sacks per game (ranked top-25) and labeled as the top pass defense in the nation (125.8 YPG).
On offense, the Buckeyes can match Indiana. Julian Sayin has 3,065 passing yards and 30 TDs. His top target, Jeremiah Smith, has produced 942 yards and 11 touchdowns, while Carnell Tate adds 793 yards and eight scores. Bo Jackson’s 952 rushing yards give the Buckeyes balance too.
Indiana’s defense is better than people think. The Hoosiers allowed multiple touchdowns just once in the last six games and opponents have scored fewer than 17 points in five of their last six. But they haven’t faced a complete offense like this since Oregon (Week 7), where they held the lead for a 30-20 dub. Notably, those Ducks rank higher in scoring offense (36.3 PPG) and rushing (215.3 YPG) than the Buckeyes. But, Ohio State has a slightly better receiver room (257 YPG) compared to Oregon (246.4 YPG).
Interestingly, both teams faced five of the same opponents this season (Purdue, Wisconsin, Penn State, UCLA, Illinois). Indiana’s average margin in those games was 36.6 points, while Ohio State’s was 27.6. Specifically, each sharing a ranked meeting with Illinois is something to look at. That matchup was Ohio State's worst defensive performance (34-26) while Indiana dominated against a then-No. 9 Illinois, 63-10. Similarly, both hosted UCLA in the second-half of the season with the Bucs winning 48-10 while the Hoosiers shined a better 56-6 victory.
This points toward a game dominated by controlled drives. Indiana averages 29.4 seconds per play, Ohio State 31.8, the longest mark in the nation. Both quarterbacks protect the football, so turnovers are unlikely, and both teams will methodically manage the clock.
Indiana vs Ohio State Pick: UNDER 48.5 Points (-115)
*Pick made December 2nd
*As of Dec. 4th, the total has dropped to 47.5 points. Shopping around will guarantee you find the best odds
indiana vs ohio state Prop Bet
Fernando Mendoza Anytime TD (+320)
As highlighted above, both teams have a threatening pair of receivers and a lethal running back. But Indiana has an edge Ohio State doesn’t; a quarterback who can make things happen with his legs. Mendoza has nearly 250 rushing yards this season and has rushed for a touchdown in four of his last five games. Sayin can't say that same, with just 27 rushing yards and 0 rushing TDs.
As I said, I'm expecting a methodical game with both teams leaning on the run to get down the field. All of Mendoza’s touchdowns have come inside the 20-yard line, with four in the red zone, showing he can capitalize in tight spaces. Not to mention, with Heisman voters watching, the junior will take any chance to show off.
indiana vs ohio state Betting Trends
- According to our NCAAF database, the UNDER has hit in nine of the last 10 and seven-straight games when Ohio State is a road favorite of 4.5-points or more
- Indiana is 4-1 ATS (2-3 SU) when entering as an underdog of 4.5-points or more
- Per Outlier, the UNDER hit in five of Indiana's last six games vs. top 25 scoring defenses
