Penn State heads to The Shoe to take on Ohio State in Week 10 college football action. The Nittany Lions are 3-4, including 0-4 in Big Ten play. The Buckeyes have enjoyed a much better season, bringing a 7-0 record and the No. 1 AP Poll ranking into the game. While the Nittany Lions haven't been winning as of late, they have been keeping games close.
Penn State vs Ohio State Odds
Matchup Page: Penn State vs Ohio State, Nov. 1, 12:00 pm ET
| Team | Spread | Moneyline | Total |
|---|---|---|---|
| Penn State Nittany Lions | +18.5 (-115) | +810 | OVER 44.5 (-110) |
| Ohio State Buckeyes | -18.5 (-105) | -1350 | UNDER 44.5 (-110) |
Odds as of November 1st, 2025 at FanDuel
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Penn State vs Ohio State Pick
Penn State vs Ohio State Pick: Penn State +20.5, -105 at FanDuel
Penn State has struggled to cover this season, but that's largely because it's been losing outright as favorites. However, the Nittany Lions were able to cover as an underdog against Iowa in their last game. They've only lost their four games by a combined 13 points, including holding their own in a six-point loss to No. 6 Oregon.
The Nittany Lions have also done a good job of scoring this season, which will be relevant against the Buckeyes' No. 1 scoring defense. Penn State is averaging 34 points per game, which is good for 37th in the nation and only a hair behind Ohio State's 36.4 ppg. The Buckeyes' elite defensive unit has only surrendered 5.9 ppg, but Penn State is far from terrible in this regard. The Nittany Lions' defense has given up 19.4 ppg, ranking 29th in the country.
The Buckeyes have struggled to cover against Penn State in recent years, too. The Nittany Lions are 6-3 ATS in their last nine matchups against Ohio State despite being 1-8 SU. The largest margin of victory in any of those games was 13 points (38-25 OSU in 2020, 44-31 OSU in 2022), a good bit shy of the 20.5 points that Penn State needs to stay within to cover this week.
*Pick made Oct. 27th at 2:45 pm prior to line movement
Penn State vs Ohio State Prop Pick
Penn State vs Ohio State Prop Pick: Kaytron Allen Anytime TD, +220 at FanDuel
I really like getting plus-money for Allen to score an anytime touchdown against the Buckeyes. The 5-foot-11, 217-pounder has been one of the few bright spots for Penn State this season, rushing for 612 yards and nine touchdowns while averaging 6.2 yards per carry. He's consistently found the end zone, too, scoring at least once in every game this season.
*Pick made Oct. 27th at 2:45 pm prior to line movement. Allen is +180 to score as of Oct. 30 at 11:56 am
Penn State vs Ohio State Betting Trends
- Penn State is 6-3 ATS in its last nine games against Ohio State
- The total has gone UNDER in five of Ohio State's last seven games against Penn State
- Ohio State QB Julian Sayin has thrown at least two touchdowns in all but one game this season, and at least three touchdowns in four games
