The Houston Astros (28-16) are 8-2 in their last 10 games against the Cleveland Guardians after splitting the first two games of this three-game set. Houston will try to earn the win as a Guardians vs Astros prediction favorite in Wednesday’s series finale in Houston.
- Date/Time: May 25, 8:10 p.m. ET
- Stadium: Minute Maid Park
- TV Coverage: ATSW, BSGL
- Sportsbook Guardians vs Astros Odds: Astros -196 | O/U 8
- Guardians vs Astros Betting Matchup Report
Guardians vs Astros Odds & Analysis
Sportsbook Odds
The Astros opened as -196 favorites before betting action on Cleveland as the preferred Guardians vs Astros prediction bumped the line down to Houston -180. Cleveland is going off as a +165 road underdog and the total in this AL matchup is set at 8 runs. The UNDER is 4-1 in Cleveland’s last five games.
Get the best Guardians vs Astros odds and lines available from our recommended sportsbooks for your favorite picks of the night.
- Best Spread-128+108CLE+1.5-1.5HOU
- Best Moneyline+164-178CLEHOU
- Best Total-112-108Over88Under
Starting Pitchers
Cal Quantrill allowed only one earned run in seven innings pitched last Thursday in a 4-2 Guardians loss to the Cincinnati Reds. Quantrill carries a solid 3.48 ERA and a 1.19 WHIP into this start, but the Guardians are just 1-5 in his last six trips to the mound, giving him only 2.67 runs per game of support on offense over that stretch.
Cristian Javier took a tough-luck loss on Friday when he pitched six innings and allowed three hits and one earned run in a 3-0 defeat at home to the Rangers. Javier has recorded a 2.87 ERA, a 1.02 WHIP and 39 strikeouts in 31.1 innings this season.
Cleveland Has Struggled On Offense During Recent Slump
The Guardians fell to 3-7 over their last 10 games after losing 7-3 to the Astros on Tuesday night. Cleveland has scored three runs or less six times over that 10-game stretch while averaging only 3.6 runs per game. This is in sharp contrast to the 7.4 runs that the Guardians averaged in the 8-2 stretch that came prior to this recent slump.
Jose Ramirez has been Cleveland’s top offensive performer in 2022, leading the club in batting average (.293), home runs (11), and RBIs (43). Bettors taking Cleveland as their Guardians vs Astros prediction will be hoping Ramirez can lead the offense to a big night on Wednesday.
Houston Has Cooled Off A Bit Since Red-Hot Start To May
The Astros bounced back from a 6-1 loss on Monday against Cleveland with a 7-3 win, fueled by Kyle Tucker’s three-run home run in the fifth inning. Houston is now 6-5 over its last 11 games after going a perfect 11-0 in its previous 11.
On this current 11-game stretch, Houston is 5-0 when coming off a loss and 1-5 when coming off a win. The Astros will be trying to buck that trend in the final game of their seven-game homestand Wednesday night.
Guardians vs Astros Pick & Insights
Guardians: Keys To Victory
The Guardians need to give Cal Quantrill some run support. He’s pitched well enough to win in most of his starts this season but has been hung out to dry by the offense. That has to change for Cleveland to pull off an upset win as a Guardians vs Astros prediction.
Astros: Keys To Victory
Houston is 5-0 in the last five games it has scored more than one run. The Astros’ elite pitching staff sets the bar pretty low for this offense, so look for Houston to come out on top as a Guardians vs Astros pick as long as the team can scratch out a handful of runs at home.
MLB Computer Pick: Astros -200
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- Cleveland is 4-8 in its last 12 games at Houston.
- Houston is 15-5 in its last 20 games.
- The UNDER is 9-1 in Houston’s last 10 games.
