MLB Live In-Game Betting Cheat Sheet

Our MLB live betting cheat sheet will help you make in-game wagers during the 2025 MLB season.

We've got a breakdown of the teams that come back the most, the ones that blow leads, and the squads where even a one-run lead is locked up.

Below is the latest MLB live in-game betting data and if you're looking for live betting advice for MLB and several different sports, check out this live betting guide.

Best MLB Teams When Leading

Team	After Scoring First	After 5th Inning	After 7th Inning
Chicago Cubs	68-21	76-11	83-7
Cleveland	66-21	55-7	69-4
Detroit	69-22	66-13	77-8
Milwaukee	68-22	74-8	85-5
Houston	56-19	59-8	71-4
Philadelphia	67-23	67-13	79-5
LA Dodgers	66-25	70-10	91-10
Toronto	60-23	71-7	81-9
Boston	64-25	59-13	72-4
NY Yankees	76-30	77-18	81-5
Texas	59-25	61-18	67-8
Baltimore	53-23	50-15	63-10
Miami	50-22	52-7	61-5
Athletics	52-23	53-12	61-5
San Diego	61-27	61-9	77-5
Seattle	59-27	61-14	74-3
Tampa Bay	52-24	55-16	63-11
St. Louis	54-25	54-7	63-4
Pittsburgh	53-26	47-12	56-5
San Francisco	59-32	53-10	61-8
Atlanta	45-25	51-10	57-8
Kansas City	57-32	56-13	65-5
NY Mets	59-35	63-15	69-8
Washington	47-29	47-9	54-3
Minnesota	46-29	50-13	58-8
Cincinnati	49-32	54-11	72-7
Arizona	50-33	59-20	67-13
LA Angels	44-32	45-13	44-4
Chicago White Sox	43-33	41-18	50-10
Colorado	24-35	30-11	31-6

Simply put, this chart shows the best (and worst) MLB teams at holding leads.

I'd look closest at the After 5th and After 7th inning columns. Squads with great records and profits in those columns likely have lock-down bullpens you don't want to bet against. But, teams with bad records and negative profits, despite entering leads late, could have suspect relief pitching you can try to bet against. Locking in a late-game wager against these leading teams could work out.

For a current example, the magic 2025 Guardians are the most profitable squad in baseball when leading. Cleveland went on a torrid run, making up a 15-game AL Central gap on the Tigers from July to September. And, as the chart indicates, Cleveland makes a habit of holding its early leads during that stretch of elite baseball. Keep that in mind as the Guards barrel toward the postseason.

MLB Betting Reports

Best MLB Teams When Losing

Team	After Scoring Second	After 5th Inning	After 7th Inning
LA Dodgers	40-48	16-50	6-53
Toronto	44-53	21-51	12-58
Seattle	37-51	15-56	10-60
Cincinnati	34-49	8-59	4-63
Milwaukee	32-49	13-42	7-61
Philadelphia	30-46	12-42	4-55
San Diego	30-47	19-57	6-62
Arizona	30-49	14-50	8-65
Houston	31-56	16-59	6-66
NY Mets	24-44	10-56	6-69
Chicago Cubs	28-53	6-50	4-60
Kansas City	25-48	13-55	4-64
Boston	26-50	18-51	5-58
Atlanta	31-61	17-63	10-67
NY Yankees	21-42	8-45	6-57
LA Angels	28-58	11-65	7-76
Miami	29-61	14-66	9-68
San Francisco	22-49	13-50	11-65
Cleveland	23-54	15-55	7-65
Tampa Bay	25-61	13-58	9-67
St. Louis	24-59	11-66	8-69
Texas	22-56	8-52	7-55
Detroit	22-57	9-52	3-58
Athletics	24-63	6-63	3-74
Minnesota	23-63	12-58	4-70
Baltimore	22-64	9-62	6-68
Washington	19-67	11-75	8-91
Pittsburgh	18-65	5-56	4-75
Chicago White Sox	17-69	11-60	5-77
Colorado	19-84	7-93	8-106

The top teams when losing are the comeback kings. These are the squads that it's worth tossing a late-game wager on, even when they're losing.

If you can find the ideal combination of a squad that ranks high on this chart that's playing against a team with a bad record when leading late, upset watch is on.

More Live MLB Betting Tips

Here are a few more general trends to keep in mind when making in-game baseball wagers:

How is the bullpen of the team you’re betting on performing? If it’s been locking down opposing offenses and is injury-free, don’t hesitate to pull the trigger. We’ve broken down the best bullpens in baseball to bet on and fade.
Live betting is often all about timing. Did the big favorite go down by a run in the first inning? If so, this might be a spot to jump on as they’ll be offering much better odds than they were before the game.
Sometimes a starting pitcher just doesn’t have it. His velocity is down and his breaking balls aren’t moving the way they should be. Pay close attention to the in-game commentary as this could indicate that the pitcher could implode in upcoming innings.
Did any players leave the game due to injury or they were pinch-hit for? This could have a major impact on a team’s ability to score runs.
Check out our daily MLB betting trends and expert picks to gain an edge!