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Clemson Untouchable At Memorial Stadium

Home-field advantage has been taken to another level for Clemson, as the Tigers have won 11 straight true home games while outscoring opponents by an average of 31.5 points per game. That streak does come with a caveat, as the team did not face a single ranked opponent in that span. That will change when Clemson plays host to the Louisville Cardinals and Heisman favorite Lamar Jackson on Saturday.

Shark Bites
  • The total has gone UNDER in 12 of Clemson's last 16 games against teams with winning records.
  • Clemson is 5-0 SU and 4-1 ATS in its last 5 games in Week 5.
  • The total has gone OVER in 8 of Louisville's last 9 games.

Clemson’s defense has been absolutely dominant over the past two games, as they have surrendered just seven points and 226 yards – keep in mind those games came against South Carolina State and Georgia Tech. The offense still hasn’t fully caught up to its play of last season but has done a much better job protecting to football, with just one turnover in the past two games compared with five in the first two.

Jackson has led Louisville to the top-ranked offense in the nation, as the club is averaging 682 yards and 63.5 points per game so far this season. To put Jackson’s offense into perspective, he has passed for the ninth-most yards in the country while rushing for the fifth-most yards.

Opening Odds & Computer Pick

On the betting opening line for this matchup, the Clemson Tigers sat as -3.5-point favorite, according to 5Dimes. The total had not been posted early in the week, so check the lines pages for the latest.

Odds Shark computer prediction formulas pick a 42-37 win for the Cardinals on Saturday. View the computer score prediction and who will win the pick on the moneyline for all upcoming NCAAF matchups here.

Louisville Cardinals vs Clemson Tigers Matchup

Team Betting Records & Power Rankings

Clemson battles the Louisville Cardinals, currently with a 4-0 mark (4-0 ATS). The over under records, important for totals betting, are 0-4 for the Tigers and 4-0 for the Louisville Cardinals. Stay Informed: follow us on Twitter for odds specials, betting line moves and Clemson vs Louisville injuries news.

It's a betting matchup between the No. 14-rated Clemson Tigers and the No. 8-ranked Louisville Cardinals, according to the NCAA College Football Power Rankings here at Odds Shark.

Statistical Matchup

Offensively, the game matches up the Clemson Tigers No. 53-ranked offense (33.5 PPG) against a Louisville Cardinals defense that ranks No. 47 at 22.5 PPG. The Clemson Tigers passing attack has averaged 293 yards per game, more than the Louisville Cardinals give up through the air (156.25 YPG on average).

Defensively, the Louisville Cardinals feature the league's No. 44-rated road run defense, allowing 140.5 yards per game. Clemson, meanwhile, ranks No. 82 in rushing offense at home.

Recent Outings Betting Recap

Lamar Jackson led the way last time out for the Cardinals, connecting for 417 passing yards and a 59-28 victory over the Thundering Herd at Joan C. Edwards Stadium.

In their last game, Clemson's aerial attack generated 304 yards and the Tigers came away with a 26-7 victory over Georgia Tech at Bobby Dodd Stadium.

Betting Trends
  • Louisville is 5-0 ATS in its last 5 games
  • Louisville is 5-0 SU in its last 5 games
  • The total has gone OVER in 8 of Louisville's last 9 games
  • Louisville is 10-4 ATS in its last 14 games on the road
  • Clemson is 5-2 ATS in its last 7 games
  • Clemson is 21-1 SU in its last 22 games
  • The total has gone UNDER in 5 of Clemson's last 6 games
  • Clemson is 19-1 SU in its last 20 games at home

Next Betting Matchups

Louisville home to Duke, Friday, October 14th
Clemson at Boston College, Friday, October 7th