Last February, quarterbacks Peyton Manning and Andrew Luck teamed up on the AFC's Pro Bowl team.
But Sunday night's nationally televised game will receive a lot more hype and is the biggest game on the NFL card this weekend, as it marks the first time Manning returns to Indianapolis since being released by the Colts and signed by Denver in March 2012.
Both offensive leaders have avoided talking about one another, but it's unavoidable - the top billing for this weekend is Manning vs. Luck.
At Sportsbook, Denver is laying -7 despite having lost five in a row both straight-up and against the spread versus the Colts. Of course, those were five games when Manning was under center for Indianapolis. The Colts, meanwhile have won and covered seven straight as a home underdog and roll in on home winning streaks of 11-2 SU and 10-3 ATS.
They'll have their hands full with the league's No. 1 offense and a Broncos team that is on road winning streaks of 8-0 SU and 6-2 ATS.
In a huge division rivalry, Philadelphia is laying -3 to visiting Dallas in a battle for first place in the NFC East. Quarterback Michael Vick practiced on a limited basis Tuesday; there is still no word on his status. The Eagles have won consecutive games after a three-game slide, and come in having covered four of their last five against Dallas.
With Philly's new explosive offense, Dallas quarterback Tony Romo playing well, and the OVER on a 6-1 run when the Eagles play intradivision games, a high-scoring game wouldn't be a surprise.
Kansas City, which is keeping pace with the Broncos in the AFC West, looks to remain perfect this season at home against the Texans. It'll be a battle of defensive units, as the Texans have the league's No. 1 stop unit and Kansas City comes in with the fifth-best defense. Houston has been a cash cow before a bye week, punching the ticket 8 of 11 times.
Conversely, the Texans are mired in a 0-6 ATS skid on the road. The Chiefs are -7 in this game.
Week 7 NFL betting trends
Seattle -6.5 Arizona 40.5 Oct-17
Cardinals 7-1 SU & ATS past 8 games vs Seattle
Seahawks 1-6 ATS past 7 visits to Arizona (over is 6-1)
Cardinals lost 7 straight SU within the division
Tampa Bay 42 Atlanta -9 Oct-20
Falcons 3-8-1 ATS past 12 games vs Tampa Bay
Bucs are 11-4 ATS past 15 visits to Atlanta
Falcons UNDER is 10-3 past 13 seasons after a bye week
St. Louis 41.5 Carolina -5.5 Oct-20
Rams are 2-8 SU & ATS past 10 vs Carolina
Panthers 5-1 ATS past 6 at home vs Rams
Cincinnati 46 Detroit -3 Oct-20
Bengals 7-1 SU & ATS vs Lions since 1983
OVER is 7-1 past 8 Lions home games when favored
San Diego -8 Jacksonville 44 Oct-20
All five career meetings played OVER the total
Jaguars played 6 straight UNDERs as home underdog
Jaguars only been double-digit home dogs four times (4-0 ATS)
Chargers OVER is 13-1 past 14 seasons before a bye week
Buffalo 41 Miami -10.5 Oct-20
Dolphins UNDER is 5-1 past 6 seasons after a bye week
Dolphins UNDER is 6-1 past 7 games at home to Buffalo
Dolphins 7-3 SU & ATS past 10 vs Bills
Dolphins 1-8 ATS in nine games as double-digit home chalk since 1992
Bills 2-9 ATS past 11 games as road underdog
Bills double-digit road dog 28 times since 1984, won once
New England -4.5 NY Jets 43.5 Oct-20
Patriots 12-2 ATS past 14 trips to New York Jets
OVER is 7-1 past 8 meetings
Pats 1-4-1 ATS past 6 games as road favorite
Dallas 56 Philadelphia -2.5 Oct-20
Eagles 4-1 ATS past 5 vs Cowboys
OVER is 6-1 past 7 Eagles divisional games
Chicago EV Washington 51 Oct-20
Bears are 2-10 SU past 12 games vs Washington
OVER is 8-1 past 9 Bears road games
Bears 4-1 ATS past 5 years before a bye week
San Francisco -6 Tennessee 38.5 Oct-20
Titans 6-0-1 ATS in seven games vs 49ers since 1987
49ers 5-1 ATS past 6 as road favorite
Houston 39.5 Kansas City -4.5 Oct-20
Texans 8-3 ATS lifetime before a bye week
Texans 0-6 ATS past 6 road games
UNDER is 7-1-1 past 9 KC home games
Cleveland 46.5 Green Bay -11 Oct-20
Browns 1-15 SU past 16 as road dog (won their last game)
Packers 9-2 ATS past 11 as double-digit home chalk
Baltimore 40.5 Pittsburgh -1.5 Oct-20
Ravens OVER is 7-2-1 past 10 trips to Pittsburgh
UNDER is 10-1 past 11 Steelers games as favorites
Denver -6 Indianapolis 56 Oct-20
Broncos 0-5 SU & ATS past 5 vs Colts
Colts 7-0 SU & ATS past 7 games as home underdog
OVER is 6-1 past 7 meetings
Colts 11-2 SU, 10-3 ATS past 13 at home
Broncos won 8 straight road games (6-2 ATS)
Minnesota 47 NY Giants -2.5 Oct-21
Vikings 2-8 ATS past 10 MNF (Oct. 21 at NYG)
OVER is 7-1 past 8 Vikings MNF games
Vikings 4-1 ATS in 5 games at NY Giants since 1997