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Baseball is back.
Even a 100-day labor dispute couldn’t keep us away for long, as the 2022 MLB season is set to begin on April 7, 2022. While the delayed schedule and some bad weather will cost us a full slate of games on Thursday, we still have seven games to handicap starting off with the Milwaukee Brewers and Chicago Cubs at 2:20 p.m. ET.
Online sportsbook Bovada has released the betting lines for Opening Day with the Cardinals and Braves being the largest favorites at -200. The closest clash is between the Angels and Astros, when Shohei Ohtani makes his first start on Opening Day.
Below, we list off our two locks for the day, as well as all Opening Day odds for you to bet on. You can lock in your MLB Opening Day bets over at one of our top baseball betting sites, Bovada:
New to betting on MLB? Check out our baseball betting tutorial to help you get in on the action. Also, keep an eye on our MLB odds page for the latest up-to-date betting lines.
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2022 MLB Opening Day Odds Best Bets
Houston Astros (+104)
Shohei Ohtani is dynamic and must-watch television, but we’re going to bet against him on Opening Day this year. The Astros were one of the few teams that got to Ohtani last year, tagging him for six runs in 3.1 innings in a September start. Houston had the best offense in baseball last year and it was particularly potent against righties.
The Angels, on the other hand, were particularly mediocre against lefties last year, posting a team wRC+ of 102. With southpaw Framber Valdez on the bump for the Astros and a strong bullpen behind him, we’ll take the value on Houston.
Royals/Guardians UNDER 8.0 (-115)
Last year, both Cleveland and Kansas City ranked in the bottom 10 offensively against right-handed pitchers. Aside from the call-up of Bobby Witt Jr. for the Royals, neither squad did much to change its offensive profile heading into 2022.
With Cy Young candidate Shane Bieber dealing for Cleveland and the crafty Zack Greinke returning to Kansas City and starting on Opening Day, this looks like a low-scoring contest to us.
Find complete odds below for all Opening Day games, and lock in your baseball bets over at Bovada:
April 7, 2022: All MLB Opening Day Odds
Brewers vs Cubs Opening Day Odds
| Team | Starter | Runline | Moneyline | Totals |
|---|---|---|---|---|
| Milwaukee Brewers | Corbin Burnes | -1.5 (-120) | -195 | O 10.0 (-110) |
| Chicago Cubs | Kyle Hendricks | +1.5 (EVEN) | +160 | U 10.0 (-110) |
Odds as of April 7 at Bovada
Mets vs Nationals Opening Day Odds
| Team | Starter | Runline | Moneyline | Totals |
|---|---|---|---|---|
| New York Mets | Tylor Megill | -1.5 (+120) | -135 | O 9.0 (-120) |
| Washington Nationals | Patrick Corbin | +1.5 (-140) | +113 | U 8.0 (EVEN) |
Odds as of April 7 at Bovada
Guardians vs Royals Opening Day Odds
| Team | Starter | Runline | Moneyline | Totals |
|---|---|---|---|---|
| Cleveland Guardians | Shane Bieber | -1.5 (+135) | -128 | O 8.0 (-105) |
| Kansas City Royals | Zack Greinke | +1.5 (-160) | +107 | U 8.0 (-115) |
Odds as of April 7 at Bovada
Pirates vs Cardinals Opening Day Odds
| Team | Starter | Runline | Moneyline | Totals |
|---|---|---|---|---|
| Pittsburgh Pirates | JT Brubaker | +1.5 (-115) | +165 | O 9.0 (-110) |
| St. Louis Cardinals | Adam Wainwright | -1.5 (-105) | -200 | U 8.0 (-110) |
Odds as of April 7 at Bovada
Reds vs Braves Opening Day Odds
| Team | Starter | Runline | Moneyline | Totals |
|---|---|---|---|---|
| Cincinnati Reds | Tyler Mahle | +1.5 (-115) | +165 | O 8.0 (-105) |
| Atlanta Braves | Max Fried | -1.5 (-105) | -200 | U 8.0 (-105) |
Odds as of April 7 at Bovada
Astros vs Angels Opening Day Odds
| Team | Starter | Runline | Moneyline | Totals |
|---|---|---|---|---|
| Houston Astros | Framber Valdez | +1.5 (-180) | +104 | O 8.5 (-120) |
| Los Angeles Angels | Shohei Ohtani | -1.5 (+155) | -124 | U 8.5 (EVEN) |
Odds as of April 7 at Bovada
Padres vs Diamondbacks Opening Day Odds
| Team | Starter | Runline | Moneyline | Totals |
|---|---|---|---|---|
| San Diego Padres | Yu Darvish | -1.5 (EVEN) | -160 | O 9.0 (-100) |
| Arizona Diamondbacks | Madison Bumgarner | +1.5 (-120) | +134 | U 9.0 (-110) |
Odds as of April 7 at Bovada
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