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MLB Opening Day Betting Odds and picks

Baseball is back.

Even a 100-day labor dispute couldn’t keep us away for long, as the 2022 MLB season is set to begin on April 7, 2022. While the delayed schedule and some bad weather will cost us a full slate of games on Thursday, we still have seven games to handicap starting off with the Milwaukee Brewers and Chicago Cubs at 2:20 p.m. ET.

Online sportsbook Bovada has released the betting lines for Opening Day with the Cardinals and Braves being the largest favorites at -200. The closest clash is between the Angels and Astros, when Shohei Ohtani makes his first start on Opening Day.

Below, we list off our two locks for the day, as well as all Opening Day odds for you to bet on. You can lock in your MLB Opening Day bets over at one of our top baseball betting sites, Bovada:

New to betting on MLB? Check out our baseball betting tutorial to help you get in on the action. Also, keep an eye on our MLB odds page for the latest up-to-date betting lines.

See Odds Shark’s Best MLB Sites

2022 MLB Opening Day Odds Best Bets

Houston Astros (+104)

Shohei Ohtani is dynamic and must-watch television, but we’re going to bet against him on Opening Day this year. The Astros were one of the few teams that got to Ohtani last year, tagging him for six runs in 3.1 innings in a September start. Houston had the best offense in baseball last year and it was particularly potent against righties.

The Angels, on the other hand, were particularly mediocre against lefties last year, posting a team wRC+ of 102. With southpaw Framber Valdez on the bump for the Astros and a strong bullpen behind him, we’ll take the value on Houston.

Royals/Guardians UNDER 8.0 (-115)

Last year, both Cleveland and Kansas City ranked in the bottom 10 offensively against right-handed pitchers. Aside from the call-up of Bobby Witt Jr. for the Royals, neither squad did much to change its offensive profile heading into 2022.

With Cy Young candidate Shane Bieber dealing for Cleveland and the crafty Zack Greinke returning to Kansas City and starting on Opening Day, this looks like a low-scoring contest to us.

Find complete odds below for all Opening Day games, and lock in your baseball bets over at Bovada:

April 7, 2022: All MLB Opening Day Odds

Brewers vs Cubs Opening Day Odds

Milwaukee Brewers vs Chicago Cubs Betting Odds
Team Starter Runline Moneyline Totals
Milwaukee Brewers Corbin Burnes -1.5 (-120) -195 O 10.0 (-110)
Chicago Cubs Kyle Hendricks +1.5 (EVEN) +160 U 10.0 (-110)

Odds as of April 7 at Bovada

Mets vs Nationals Opening Day Odds

New York Mets vs Washington Nationals Betting Odds
Team Starter Runline Moneyline Totals
New York Mets Tylor Megill -1.5 (+120) -135 O 9.0 (-120)
Washington Nationals Patrick Corbin +1.5 (-140) +113 U 8.0 (EVEN)

Odds as of April 7 at Bovada

Guardians vs Royals Opening Day Odds

Cleveland Guardians vs Kansas City Royals Betting Odds
Team Starter Runline Moneyline Totals
Cleveland Guardians Shane Bieber -1.5 (+135) -128 O 8.0 (-105)
Kansas City Royals Zack Greinke +1.5 (-160) +107 U 8.0 (-115)

Odds as of April 7 at Bovada

Pirates vs Cardinals Opening Day Odds

Pittsburgh Pirates vs St. Louis Cardinals Betting Odds
Team Starter Runline Moneyline Totals
Pittsburgh Pirates JT Brubaker +1.5 (-115) +165 O 9.0 (-110)
St. Louis Cardinals Adam Wainwright -1.5 (-105) -200 U 8.0 (-110)

Odds as of April 7 at Bovada

Reds vs Braves Opening Day Odds

Cincinnati Reds vs Atlanta Braves Betting Odds
Team Starter Runline Moneyline Totals
Cincinnati Reds Tyler Mahle +1.5 (-115) +165 O 8.0 (-105)
Atlanta Braves Max Fried -1.5 (-105) -200 U 8.0 (-105)

Odds as of April 7 at Bovada

Astros vs Angels Opening Day Odds

Houston Astros vs Los Angeles Angels Betting Odds
Team Starter Runline Moneyline Totals
Houston Astros Framber Valdez +1.5 (-180) +104 O 8.5 (-120)
Los Angeles Angels Shohei Ohtani -1.5 (+155) -124 U 8.5 (EVEN)

Odds as of April 7 at Bovada

Padres vs Diamondbacks Opening Day Odds

San Diego Padres vs Arizona Diamondbacks Betting Odds
Team Starter Runline Moneyline Totals
San Diego Padres Yu Darvish -1.5 (EVEN) -160 O 9.0 (-100)
Arizona Diamondbacks Madison Bumgarner +1.5 (-120) +134 U 9.0 (-110)

Odds as of April 7 at Bovada