The Philadelphia Eagles host the San Francisco 49ers in the NFC's wild-card round. The Eagles won the NFC East with an 11-6 record, and the 49ers finished third in the NFC West with a 12-5 record, tying with the Los Angeles Rams behind the Seattle Seahawks. The Eagles are 4.5-point favorites over the Niners after opening closer to 3.5, and the total for this playoff matchup has dropped from 46.5 to 44.5 points.
49ers vs Eagles Odds - NFC Wild Card
Matchup Page: 49ers vs Eagles, Jan 11, 4:30 pm ET
| Team | Spread | Moneyline | Total |
|---|---|---|---|
| San Francisco 49ers | +4.5 (-110) | +188 | OVER 44.5 (-105) |
| Philadelphia Eagles | -4.5 (-110) | -225 | UNDER 44.5 (-115) |
Odds as of Jan. 7th, 2026 at FanDuel
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21+ and present in OH.
49ers vs Eagles Pick - NFC Wild Card
Eagles -3.5, -120 at FanDuel
I like Philly's chances to pick up a win over the 49ers. The Eagles' defense has begun to round into form, allowing the eighth-fewest total yards per game over their last three games. And that includes the team's Week 18 matchup in which the Eagles sat plenty of starters. Only four teams allowed fewer points per game on the season than Philadelphia (19.1), and the team is seventh in turnover differential, too.
The 49ers have struggled in many of those same areas. San Francisco's defense ranks 20th in yards on the season and 23rd over its last three games. The 49ers rank 13th in points allowed per game (21.8) and 26th in turnover differential.
My biggest concern for the 49ers is their inability to generate pressure. They rank dead last in team sacks with 20 (Eagles: T12th with 42), and no one on the roster has more than four sacks (Bryce Huff and Clelin Ferrell). That should give Jalen Hurts plenty of time to find weapons or scramble, and that could be the deciding factor given the other advantages the Eagles have at home, detailed below.
San Francisco's offense has been better than Philly's on the whole, but they average about 21 fewer yards per game on the road, and the Eagles allow 36.6 fewer yards per game at home than on the road. That home success helped the Eagles post 5-3 SU and 4-4 ATS records at home this season, according to our NFL betting database.
The 49ers have been slightly better ATS, regardless of location (7-3), in their last 10 compared to the Eagles (6-4), but the Eagles posted three consecutive outright victories and covers before Week 18 when the team started Tanner McKee at quarterback. The 49ers haven't been great as underdogs, though. They've gone 1-7 ATS in their last eight games as an underdog, according to Outlier betting insight tools.
*Pick made Jan. 5th at 2:30 pm ET prior to line movement. The change from 3.5 to 4.5 is a bit unfortunate, but moving from -120 to -110 helps soften that blow a bit. I'd still take the Eagles at -4.5, but I'd feel a bit less confident.
49ers vs Eagles Prop Pick - NFC Wild Card
Jalen Hurts Anytime Touchdown, +110 at FanDuel
I love getting Hurts to score a touchdown at plus-money given his playoff history. Hurts has scored at least one rushing touchdown in six of his nine career playoff games, totaling 10 scores in those contests. The 49ers only allowed one rushing touchdown to quarterbacks, but I still trust Hurts and the 'Tush Push' to find the end zone at least once.
*Pick made Jan. 5th at 2:51 pm ET
49ers vs Eagles Betting Trends
- The Eagles went 3-0 SU and ATS in their last three games prior to Week 18, according to our NFL betting database.
- The 49ers are 1-7 ATS in their last eight games as an underdog, per Outlier.
- Eagles QB Jalen Hurts has exceeded 29.5 rushing yards in 13 of his last 16 home games, per Outlier.
