Chiefs vs Bills Odds & Picks Week 9

The Kansas City Chiefs vs. Buffalo Bills Week 9 matchup was one that a lot of fans circled when the NFL schedule was released. Buffalo (5-2 SU, 3-4 ATS) will be looking for revenge against the Chiefs (5-3 SU, 5-3 ATS), who knocked them out of the playoffs in 2020, 2021, 2023, and 2024.

The Chiefs are favored by 2 points and the total is set at 52.5, which is just under the key number of 53. This game may go a long way to determining who wins the MVP Award, because both starting quarterbacks are also the top two signal callers on the odds board.

Below you can get my perspective on the epic Chiefs vs Bills Week 9 contest.

Chiefs vs Bills Odds

Matchup Page: Kansas City Chiefs vs. Buffalo Bills, November 2, 4:25 pm

**Chiefs vs Bills** **Odds**
Team	Spread	Moneyline	Total
Kansas City Chiefs	-2 (-112)	-134	Over 52.5 (-109)
Buffalo Bills	+2 (-108)	+110	Under 52.5 (-110)

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Chiefs vs Bills Picks - Week 9

Currently the forecast for this game is calling for a 64% chance of rain and 6 MPH winds, so keep an eye on NFLWeather.com as kickoff approaches.

The Chiefs will be playing on a short week after sitting two starting offensive linemen and losing Isiah Pacheco to an MCL injury. Tackle Josh Simmons will be out again this week because he's dealing with a personal matter and the status of guard Trey Smith is up in the air. Smith practiced in a limited capacity on Wednesday, which is promising. Whether Smith plays or not, it's fair to say the Bills are the healthier team as Buffalo's main injury issue is defensive tackle Ed Oliver who hurt himself last week and is out indefinitely.

I was concerned about the Bills run defense before last week, but they seemed to have figured some things out during their bye week (Week 7) and held the Panthers to 4.1 YPC. The loss of Pacheco and a banged up Kansas City offensive line helps mitigate concerns about the Chiefs leaning heavily on their running game. Meanwhile, the Chiefs should be concerned about stopping the run because Bills' running back James Cook is fresh off his best game of the season (216 yards, 2 TD).

Since 2022, the Bills have only lost two regular season games by more than eight points and that makes me feel comfortable using them +8 as a 6-point teaser leg. I'm expecting a tight back-and-forth game, but even if the Chiefs jump out to an early lead, the Bills are built for a backdoor cover with Josh Allen in the fourth quarter. I'm pairing the Bills +8 with the Ravens -1.5 teaser leg and if you want to read more about why I like the Ravens in that contest, check out my Ravens vs. Dolphins preview.

Chiefs vs Bills Week 9 Pick: Bills +8 & Ravens -1.5 via 2T, 6P Teaser (-125)

Pick Made as of Oct. 28th at 3:04 pm ET at Caesars. The Bills are still +2 and the Ravens are still -7.5 as of today, so this teaser is still available.

Chiefs vs Bills Props - Week 9

The Bills have struggled at times to contain rushing quarterbacks this season. Lamar Jackson (70 rushing yards and a touchdown in Week 1), Tyrod Taylor & Justin Fields (combined for 78 rushing yards in Week 2), and Spencer Rattler ( 49 rushing yards in Week 4) all saw success on the ground vs. Buffalo. Meanwhile, Patrick Mahomes has rushed for at least 28 yards in four straight games. The last time Mahomes faced the Bills (2024 playoffs) he ran for 43 yards and two touchdowns.

Chiefs vs Bills Week 9 Prop Pick: Patrick Mahomes OVER 27.5 rush yards (-110)

Pick Made as of Oct. 30th at 8:46 am ET at bet365