Is there anything more exhilarating than a big upset victory in the NFL? We see upsets all the time in pro football, but it somehow never ceases to amaze when a big underdog finds a way to pull off a victory over a “better” team. 

This article will look at the biggest NFL upset of the week from a betting perspective and look ahead at some potential upsets for the next slate of games. Also make sure to check out all of our NFL betting content, from NFL expert picks and Week 12 prop bets to Super Bowl odds.

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NFL Week 11 Biggest Upset: Lions 31 - Giants 18

Opening Spread: Giants -3
Moneyline: Giants -162/Lions +142

The Lions got out to an early lead last week and the Giants just couldn’t claw back. All season, Detroit has had no problem scoring, but failing to hold down opposing offenses prevented wins. This time, the Lions allowed just six Giants points through the first three quarters and coasted to an upset W.

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NFL Week 12 Upsets: Looking Ahead

NFL Upset Pick #1: Bears (+220) vs Jets

Forgive me for not buying the Mike White hype. Sure, Zach Wilson was a problem for New York at QB, but he wasn’t the problem.

The Jets’ recent issues stem from an onslaught of injuries and lack of depth. With guard Alijah Vera-Tucker, RB Breece Hall and four or five other regular offensive players injured, the Jets can’t generate any scoring. Mike White can probably come in at QB and settle things down, but he can’t make up for all the injuries.

Even star corner Sauce Gardner finds himself on the injury report as questionable this week, which would be a big blow to a strong defense.

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NFL Upset Pick #2: Jaguars (+170) vs Ravens

The Ravens are often known for a strong defense, but they’ve actually had one of the worst passing defenses in the NFL this year. Baltimore’s 249.2 yards per game allowed through the air ranks 27th.

The Jaguars have had an up-and-down passing season, but they’ve been particularly strong through the air at home. Trevor Lawrence has passed for 266.5 yards per home game this year (sixth best). With legit receiving weapons like Christian Kirk and Evan Engram, the Jags have the talent to expose Baltimore’s defensive weakness. If Lawrence can rack up the passing yards, the Ravens could get upset.

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