Buffalo Bills - NFL Schedule
| Date | Opponent | Game | Result | Score | ATS | Spread | OU | Total |
|---|---|---|---|---|---|---|---|---|
| Sep 13, 2020 | vs NY Jets | REG | W | 27-17 | W | -6.5 | O | 39 |
| Sep 20, 2020 | @ Miami | REG | W | 31-28 | L | -5.5 | O | 42.5 |
| Sep 27, 2020 | vs LA Rams | REG | W | 35-32 | W | -1.5 | O | 46.5 |
| Oct 4, 2020 | @ Las Vegas | REG | W | 30-23 | W | -3 | O | 52.5 |
| Oct 13, 2020 | @ Tennessee | REG | L | 42-16 | L | -3 | O | 52 |
| Oct 19, 2020 | vs Kansas City | REG | L | 26-17 | L | +5.5 | U | 55 |
| Oct 25, 2020 | @ NY Jets | REG | W | 18-10 | L | -9.5 | U | 46.5 |
| Nov 1, 2020 | vs New England | REG | W | 24-21 | L | -4 | O | 41 |
| Nov 8, 2020 | vs Seattle | REG | W | 44-34 | W | +3 | O | 55 |
| Nov 15, 2020 | @ Arizona | REG | L | 32-30 | W | +3 | O | 55.5 |
| Nov 29, 2020 | vs LA Chargers | REG | W | 27-17 | W | -4 | U | 51 |
| Dec 7, 2020 | @ San Francisco | REG | W | 34-24 | W | +1.5 | O | 48 |
| Dec 13, 2020 | vs Pittsburgh | REG | W | 26-15 | W | -2 | U | 48.5 |
| Dec 19, 2020 | @ Denver | REG | W | 48-19 | W | -6 | O | 48 |
| Dec 28, 2020 | @ New England | REG | W | 38-9 | W | -7 | P | 47 |
| Jan 3, 2021 | vs Miami | REG | W | 56-26 | W | +3 | O | 42.5 |
| Jan 9, 2021 | vs Indianapolis | PST | W | 27-24 | L | -7 | O | 50.5 |
| Jan 16, 2021 | vs Baltimore | PST | W | 17-3 | W | -2.5 | U | 50 |
| Jan 24, 2021 | @ Kansas City | PST | L | 38-24 | L | +3 | O | 54.5 |
