San Francisco 49ers - NFL Schedule for 2021
| Date | Opponent | Game | Result | Score | ATS | Spread | OU | Total |
|---|---|---|---|---|---|---|---|---|
| Aug 14, 2021 | vs Kansas City | PRE | L | 19-16 | L | -2.5 | U | 38.5 |
| Aug 22, 2021 | @ LA Chargers | PRE | W | 15-10 | L | -6.5 | U | 35 |
| Aug 29, 2021 | vs Las Vegas | PRE | W | 34-10 | W | -5.5 | O | 36 |
| Sep 12, 2021 | @ Detroit | REG | W | 41-33 | L | -9.5 | O | 46 |
| Sep 19, 2021 | @ Philadelphia | REG | W | 17-11 | W | -3 | U | 49 |
| Sep 26, 2021 | vs Green Bay | REG | L | 30-28 | L | -3 | O | 50.5 |
| Oct 3, 2021 | vs Seattle | REG | L | 28-21 | L | -2.5 | U | 52 |
| Oct 10, 2021 | @ Arizona | REG | L | 17-10 | L | +6 | U | 48.5 |
| Oct 24, 2021 | vs Indianapolis | REG | L | 30-18 | L | -3.5 | O | 41.5 |
| Oct 31, 2021 | @ Chicago | REG | W | 33-22 | W | -4.5 | O | 40 |
| Nov 7, 2021 | vs Arizona | REG | L | 31-17 | L | -5.5 | O | 44.5 |
| Nov 15, 2021 | vs LA Rams | REG | W | 31-10 | W | +3.5 | U | 50 |
| Nov 21, 2021 | @ Jacksonville | REG | W | 30-10 | W | -6.5 | U | 45.5 |
| Nov 28, 2021 | vs Minnesota | REG | W | 34-26 | W | -4 | O | 49 |
| Dec 5, 2021 | @ Seattle | REG | L | 30-23 | L | -3 | O | 44.5 |
| Dec 12, 2021 | @ Cincinnati | REG | W | 26-23 | W | -1 | U | 49.5 |
| Dec 19, 2021 | vs Atlanta | REG | W | 31-13 | W | -9 | U | 48 |
| Dec 23, 2021 | @ Tennessee | REG | L | 20-17 | L | -3.5 | U | 45.5 |
| Jan 2, 2022 | vs Houston | REG | W | 23-7 | W | -13.5 | U | 44 |
| Jan 9, 2022 | @ LA Rams | REG | W | 27-24 | W | +3.5 | O | 46.5 |
| Jan 16, 2022 | @ Dallas | PST | W | 23-17 | W | +3.5 | U | 51 |
| Jan 22, 2022 | @ Green Bay | PST | W | 13-10 | W | +6 | U | 47 |
| Jan 30, 2022 | @ LA Rams | PST | L | 20-17 | W | +3.5 | U | 45.5 |
