San Diego Padres at Cleveland Indians Betting Lines and Pick

The San Diego Padres will look to pick up a road win when they take on the Indians in Cleveland at Progressive Field on Wednesday in MLB baseball betting odds action.

It's a pitching duel between Trevor Bauer for the Cleveland Indians (7-6 on the year) and Luis Perdomo for San Diego Padres (3-4 so far).

Sportsbook Odds & Computer Pick

Cleveland was a -223 moneyline favorites earlier in the day at Sportsbook, based on the starting pitcher matchup. That pairing made odds makers at Sportsbook pick an Sportsbook over under number of 9.5.

Odds Shark computer prediction formulas pick a 5.4-2.8 win for the Indians on Wednesday. View the computer score prediction and who will win the pick on the moneyline for all upcoming MLB matchups here.

San Diego Padres vs Cleveland Indians Matchup

Team Betting Records & Power Rankings

The Cleveland Indians bring a 44-38 record to the battle against the 35-48 Padres. Stay Informed: follow us on Twitter for odds specials, betting line moves and Cleveland vs San Diego injuries news.

The MLB Power Rankings show a disparity between these teams, with the Cleveland Indians rated this week at No. 2 and the San Diego Padres sitting at No. 15.

Statistical Matchup

Scoring stats point to some edges in this matchup. The game features the Cleveland Indians No. 15-ranked scoring average of 4.76 runs per game, against a San Diego Padres offense rated No. 30 and scoring 3.58 runs per game. The Indians have averaged 8.67 hits per game to date this season, more than the Padres hitters have managed (7.46 per nine innings).

Cleveland owns the No. 3 defense, allowing 4.76 men per game to cross the plate. That contrasts with San Diego's No. 23-rated defense.