Arizona Cardinals vs San Francisco 49ers

This isn’t the way it was supposed to be for the Arizona Cardinals. They entered the season as a legitimate Super Bowl contender, but four games in, they’re 1-3 SU and have also burned bettors with a 1-3 ATS record. They’ll get the chance to turn around their season on Thursday night in San Francisco vs the 49ers, who’ve also been a stay-away at 1-3 SU and ATS.

• The 49ers are 15-6 SU and ATS in their last 21 games in October.
• The 49ers are 13-2 SU in their last 15 games at home after a loss at home.
• The Cardinals are 7-2 ATS in their last nine games after consecutive ATS losses.

As we pointed out in our Super Bowl futures update this week, it might already be too late for Arizona as only one team since 1980 has started 1-3 and gone on to win the Super Bowl.

To make matters worse for the Cards, starting QB Carson Palmer was diagnosed with a concussion following the team’s Week 4 loss to the Rams and will miss the game, paving the way for Drew Stanton to make the start, which is a significant drop-off. Stanton’s career record on the road is 7-6, with just three TD passes and nine interceptions.

The 49ers have gotten the better of the Cards when the teams meet in San Francisco, posting a 6-1 SU and 5-2 ATS record the last seven times they’ve hosted them. With Palmer possibly on the shelf, Arizona would be wise to pound the ball vs a 49ers team that’s allowed the most rushing yards in the NFL at 562. The 49ers’ leaky defensive front, along with a run-heavy game plan, should give David Johnson the opportunity to post his first 100-yard game of the season.

Sportsbook Odds & Computer Pick

The point spread was settled in at 2.5 for the host San Francisco 49ers earlier in the week, according to Sportsbook. The over under betting line was hovering around 43, with odds movement expected during the week at Sportsbook.

Handicapping prediction models run by the computers at Odds Shark pick a 24-22 result in favor of the 49ers. View the computer score prediction and who will win the pick on the moneyline for all upcoming NFL matchups here.

Arizona Cardinals vs San Francisco 49ers Matchup

Team Betting Records & Power Rankings

San Francisco will face the 1-3 Arizona Cardinals, who own a 1-3 ATS mark on the season. In totals betting, the 49ers are 2-2 so far this season while the Cardinals are 1-2-1. Stay Informed: follow us on Twitter for odds specials, betting line moves and San Francisco vs Arizona injuries news.

The game pits the San Francisco 49ers, currently No. 26 in our Odds Shark NFL Power Rankings, against the Arizona Cardinals, who rate No. 3 in the latest survey.

Statistical Matchup

Offensively, the game matches up the San Francisco 49ers No. 15-ranked offense (22.5 PPG) against a Arizona Cardinals defense that ranks No. 12 at 20 PPG. The 49ers passing attack has averaged 178.75 yards per game, less than the Cardinals give up through the air (203.25 YPG on average).

Defensively, the Arizona Cardinals feature the league's No. 32-rated road run defense, allowing 208 yards per game. The San Francisco 49ers, meanwhile, ranks No. 11 in rushing offense at home.

Recent Outings Betting Recap

John Brown hauled in 10 passes for 144 yards against the Los Angeles defense in the team's last game, but the result was a 17-13 loss against the Rams on Sunday.

In their last game, the 49ers were Week 4 losers coming out on the wrong end of 24-17 score against Dallas.

• Arizona is 1-6 ATS in its last 7 games
• Arizona is 11-5 SU in its last 16 games
• Arizona is 1-4 SU in its last 5 games
• The total has gone UNDER in 8 of Arizona's last 12 games
• San Francisco is 2-6 ATS in its last 8 games
• San Francisco is 2-6 SU in its last 8 games
• San Francisco is 4-2 ATS in its last 6 games at home
• The total has gone UNDER in 5 of San Francisco's last 5 games at home

Next Betting Matchups

Arizona home to New York, Monday, October 17th
San Francisco at Buffalo, Sunday, October 16th