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Cubs vs White Sox Prediction & Picks: White Sox Seek Fourth Straight Win Vs Cubs

The Chicago White Sox (22-22) are 7-1 SU in their last eight games against the Chicago Cubs (18-26) including a current stretch of three straight wins. The White Sox will look to keep things rolling against their Windy City rivals with a win as a Cubs vs White Sox prediction favorite this Saturday at home.

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Cubs vs White Sox Odds & Analysis

Sportsbook Odds

The White Sox opened as -161 favorites before betting action on the Cubs as a popular Cubs vs White Sox prediction drive the line on the White Sox down to -136. The Cubs are going off as a +126 underdog in this rivalry game while the total is set at 8.5 runs. The OVER is 5-1 in the Cubs’ last six road games against the White Sox.

Get the best Cubs vs White Sox odds and lines available from our recommended sportsbooks for your favorite picks of the night.

  • Best Spread
    -155
    +135
    CHC+1.5
    -1.5CHW
  • Best Moneyline
    +127
    -137
    CHC
    CHW
  • Best Total
    -105
    -115
    Over8
    8Under

Starting Pitchers

Keegan Thompson is set to make his third spot start of the season for the Cubs on Saturday. The long reliever has appeared in 10 games this season and has collected four wins while recording a 1.54 ERA and a 1.00 WHIP in 35 innings pitched.

Johnny Cueto is off to an excellent start in his first season with the White Sox. He has pitched six shutout innings in each of his first two starts on the road against the Kansas City Royals and the New York Yankees. He’ll make his White Sox home debut in this matchup sporting a 0.00 ERA and a 1.00 WHIP.

The White Sox Have Had Some Rough Pitching Performances This Month

Chicago found itself in a 6-0 hole at the end of two innings on Thursday and was unable to recover in a 16-7 loss at home to the Boston Red Sox. That marked the second time in the three-game series that the Red Sox had scored 16 runs and the fifth time this month that the White Sox have allowed 10 or more runs to an opponent.

Despite those rough patches, the White Sox are still 14-9 SU over their last 23 games. Bettors taking the White Sox as their Cubs vs. White Sox prediction on Saturday will be looking for a much better pitching effort from Johnny Cueto and the bullpen.

The Cubs Hope To Bounce Back From Ugly Loss To Cincinnati

After losing the first three games of their four-game series against the Arizona Diamondbacks last week, the Cubs wrapped up that series with a 5-4 win and picked up back-to-back wins of 7-4 and 11-4 against the Cincinnati Reds to start this week’s action. That three-game winning streak was snapped in a 4-3 loss on Wednesday and was followed up with a disastrous 20-5 loss to the lowly Reds on Thursday.

Chicago is now 3-6 SU over its last nine games after having gone 6-2 SU over its previous eight games. On the bright side for the Cubs, their offense has picked up of late with an average of 6.14 runs per game over the club’s last seven games.

Cubs vs White Sox Pick & Insights

Cubs: Keys To Victory

Keegan Thompson has pitched great this season, but he averages only 50 pitches per outing.  With Thompson likely topping out at four or five innings, the Cubs bullpen will need to step up on Saturday to help keep the White Sox offense in check to deliver an upset as a Cubs vs White Sox prediction.

White Sox: Keys To Victory

Johnny Cueto has 27 career starts against the Cubs and has compiled a 3.48 ERA and a 1.22 WHIP over that stretch. As long as Cueto continues his strong start to the season and his history of solid pitching against the Cubs, the White Sox should have a great shot to win as a Cubs vs White Sox pick.

MLB Computer Pick: White Sox -128

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Shark Bites
  • Chi Cubs are 4-2 SU over their last 6 games.
  • Chi White Sox are 7-0 SU in their last 7 games vs NL teams.
  • The OVER is 6-1 in Chi Cubs’ last 7 games.
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