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White Sox vs Twins MLB Preview

The Minnesota Twins (45-37) are 5-0 SU in their last five games against the Chicago White Sox (38-39) heading into this three-game road series against them. The Twins will look to extend their winning streak against the White Sox with an upset win as a Twins vs White Sox prediction this Monday night in Chicago.

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Twins vs White Sox Betting Preview

Twins vs White Sox Odds & Analysis

Opening Odds

The White Sox opened as a very slight favorite at -111 before betting action on them as the preferred Twins vs White Sox prediction bumped the line up to Chicago -130. Minnesota is now going off as a +110 road underdog in this AL Central matchup and the total is down to nine runs after opening at 9.5 runs. The UNDER is 6-1 in Minnesota's last seven games.

Starting Pitchers

Dylan Bundy pitched five innings and allowed six hits and two earned runs in a 7-6 extra-innings loss to the Cleveland Guardians last Wednesdsay night. Since winning in each of his first three starts in 2022, Minnesota is 1-9 SU in Bundy's last 10 starts. The right-hander is 4-4 with a 4.71 ERA and a 1.29 WHIP this season.

Johnny Cueto gave up three earned runs in six innings pitched last Tuesday night in an 11-4 White Sox win over the Los Angeles Angels. Cueto has recorded a 3.33 ERA and a 1.17 WHIP in 54 innings pitched for Chicago in 2022.

Get the best Twins vs White Sox odds and lines available from our recommended sportsbooks for your favorite picks of the night.

  • Best Spread
    -164
    +145
    MIN+1.5
    -1.5CHW
  • Best Moneyline
    +128
    -135
    MIN
    CHW
  • Best Total
    -110
    +100
    Over9
    9Under

Minnesota Has Struggled On The Road Against The White Sox

The Twins took the first two games of their weekend series at home against the Baltimore Orioles before losing the third game 3-1 on Sunday. Now Minnesota returns to the road, where the Twins are 7-10 SU over their last 17 games away from home.

While Minnesota has won five straight games against the White Sox, all five of those games came at home. The Twins enter this series with a 2-9 SU record in their last 11 road games against the White Sox with seven of those nine losses coming by two runs or more.

Chicago Is Playing Well After Weekend Sweep

The White Sox wrapped up a three-game sweep over the San Francisco Giants on Sunday with a 13-4 blowout win. Chicago outscored the Giants 19-7 over those three games and improved to 5-2 SU over the club's last seven games since going 0-4 SU over its previous four games.

The pitching staff and bullpen have been sharp over this recent stretch, allowing only 3.14 runs per game over Chicago's current 5-2 SU run. Bettors taking Chicago as their Twins vs White Sox prediction will be counting on Johnny Cueto to keep things rolling on the mound.

Twins vs White Sox Pick & Insights

Twins: Keys to Victory

The Twins haven't been at their best on offense during their current 3-4 SU skid averaging 3.57 runs per game over those seven games. Dylan Bundy will need to pitch well to give Minnesota the chance to win a low-scoring game as a Twins vs White Sox prediction upset,

White Sox: Keys to Victory

Johnny Cueto has given up exactly three earned runs in five of his last six starts. That should be what bettors who take the White Sox are expecting on Monday, meaning that Chicago's offense will need to provide their veteran starter with some run support at home to cash in as a Twins vs White Sox pick.

MLB Computer Pick:  OVER 9 Runs

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Shark Bites
  • Minnesota is 3-8 SU in its last 11 games vs AL Central teams.
  • Chicago is 4-1 SU over its last 5 games.
  • The UNDER is 7-3 in Chicago's last 10 games.