Flag Our Top Sportsbooks
50% BONUS Up To $1000
50% BONUS Up To $1000
125% BONUS Up To $2500
Aaron Judges' Yankees favored in out Yankees vs Cardinals odds

The St. Louis Cardinals (58-48) are 5-0 SU over their last five games after defeating the New York Yankees (70-37) 4-3 in Friday night's series opener. The Cardinals will try to earn another upset win at home on Saturday night as a Yankees vs Cardinals prediction to extend their winning streak.

Bet On Yankees Vs Cardinals Here

Yankees vs Cardinals Betting Preview

Yankees vs Cardinals Opening Odds

Opening Odds

The Yankees opened as -120 road favorites before settling in at New York -115 while St. Louis is going off at -105 in this interleague matchup. Bettors have leaned towards the UNDER as their preferred Yankees vs Cardinals prediction on the total in this one, bumping the line up to eight runs after it opened at 7.5 runs. The UNDER is 8-3 in the last 11 games between New York and St. Louis.

Starting Pitchers

Domingo German had his most productive start of the season in New York's 7-2 win over the Seattle Mariners on Monday, pitching five innings and allowing six hits and two earned runs. German enters his fourth start of the season with a 6.39 ERA and a 1.82 WHIP in 12.2 innings pitched.

Jordan Montgomery spent the first six seasons of his professional career with the Yankees before being traded to the Cardinals at this year's MLB Trade Deadline for outfielder Harrison Bader. Montgomery is set to make his first start for the Cardinals against his old team, bringing a 3-3 record with a 3.69 ERA and a 1.10 WHIP on the season into this start.

Get the best Yankees vs Cardinals odds and lines available from our recommended sportsbooks for your favorite picks of the night

  • Best Spread
  • Best Moneyline
  • Best Total

New York Has Cooled Off Since Dominating The First Half

The Yankees looked unbeatable during large chunks of the first half of the 2022 season, jumping out to the best record in baseball at 61-23 SU through their first 84 games. They've been far less impressive since then 9-14 SU record over their last 23 games, most recently falling to 0-3 SU over their last three games with Friday's loss in St. Louis.

New York has missed Giancarlo Stanton, who has been on the injured list with an Achilles injury since July 24. Anthony Rizzo was also a late scratch prior to Friday's game due to a back injury and is questionable to return to the lineup this weekend.

St. Louis Has Closed The Gap On Milwaukee In The NL Central

Paul DeJong played the hero on Friday night for the Cardinals, hitting a two RBI double to give St. Louis a 4-3 lead over the Yankees in the bottom of the eighth inning that they would hold on to in the ninth to improve to 7-1 SU over their last eight games. The Cardinals enter the weekend tied with the Milwaukee Brewers for first place in the NL Central with matching 58-48 SU records.

Trade deadline acquisitions of Jordan Montgomery and Jose Quintana should help shore up the Cardinals' starting pitching issues down the stretch. Bettors taking St. Louis as their Yankees vs Cardinals prediction are hoping that Montgomery can start his Cardinals career with a memorable performance in this one.

Yankees vs Cardinals Pick & Insights

Yankees: Keys To Victory

The Yankees have scored three runs or fewer in five of their last seven losses. Even with Giancarlo Stanton and potentially Anthony Rizzo out, New York still has plenty of firepower to generate runs, and the club will need to do so if it hopes to come away as the winning Yankees vs Cardinals prediction on Saturday.

Cardinals: Keys To Victory

St. Louis has outscored its opponents 26-8 over the team's current 5-0 SU winning streak. The Cardinals are in sync on offense with Paul Goldschmidt and Nolan Arenado leading the way, so look for them to cash in as a Yankees vs Cardinals pick at home if Jordan Montgomery is able to turn in a decent start against his old club.

MLB Computer Picks: Yankees ML -120

Check out more of our signature MLB computer picks, plus our favorite sportsbooks that serve baseball customers. 

Join A Top-Tier MLB Betting Site Now

Shark Bites
  • New York is 2-8 SU in its last 10 road games.
  • St. Louis is 3-7 SU in its last 10 games vs AL teams.
  • The UNDER is 4-1 in St. Louis's last 5 games.