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Nolan Arenado & Cardinals opened as slight road favourites against Brewers on April 16, 2022.

The St. Louis Cardinals (4-2) are 12-2 SU over their last 14 road games after defeating the Milwaukee Brewers (4-4) 10-1 on Friday night in Milwaukee. This four-game series continues on Saturday night with the Cardinals trying to cash in as a Cardinal vs Brewers Prediction on the road.

St. Louis Cardinals vs Milwaukee Brewers
  • Date/Time: April 16, 7:10 p.m. ET
  • Stadium: American Family Field
  • TV Coverage: MLBN, BSMW, BSWI
  • Opening Odds: Cardinals -132 | O/U 9 runs (Line History)
  • Cardinals vs Brewers Matchup Report

Cardinals vs Brewers Odds & Analysis

Opening Odds

The Cardinals opened as -132 road favorites, but betting action on Milwaukee as the preferred Cardinals vs Brewers prediction flipped the favorite as Milwaukee is now going off at -108 at home. St. Louis is sitting at -102 on the betting board while the total in this NL Central matchup has settled in at 8.5 runs after opening at nine runs. The OVER is 4-2 in St. Louis’s last six games.

Starting Pitchers

Steven Matz suffered through an awful start in his Cardinals debut last Sunday, allowing nine hits and seven earned runs in just three innings pitched to finish the game with a 21.00 ERA and a 3.33 WHIP. Matz pitched well with the Toronto Blue Jays last season, recording a 14-7 record with a 3.82 ERA and a 1.33 WHIP in 29 starts in 2021.

Adrian Houser allowed four hits and two earned runs in 3.2 innings pitched during a 2-0 loss to the Baltimore Orioles on Monday night. Houser compiled a 3.22 ERA and a 1.28 WHIP in his first full season as a starter last year and went 3-0 with a dazzling 0.36 ERA in four starts against St. Louis.

Get the best Cardinals vs Brewers odds and lines available from our recommended sportsbooks for your favorite picks of the night.

  • Best Spread
    -185
    +170
    STL+1.5
    -1.5MIL
  • Best Moneyline
    +105
    -112
    STL
    MIL
  • Best Total
    -115
    -105
    Over8
    8Under

St. Louis’s Offense Is Off To A Hot Start

The Cardinals were held to under four runs for the first time in 2022 when they lost their series opener to the Brewers 5-1 on Thursday night. The offense bounced back with a 10-run performance in Friday’s blowout win, led by Nolan Arenado going 2-for-3 with a home run, two runs and three RBI.

Arenado is off to a blistering start to the new season batting .435 with four home runs and 12 RBI. The Cardinals as a whole are averaging six runs per game through their first six games of the season. Bettors taking St. Louis as their Cardinals vs Brewers prediction will be hoping for another big day at the plate on Saturday.

Milwaukee Has Struggled Against St. Louis

Freddy Peralta was tagged for six earned runs in only three innings pitched in Friday night’s loss. Peralta was excellent last season with a 2.81 ERA and 195 strikeouts in 144.1 innings pitched, but he’s off to a terrible start in 2022 with an 11.57 ERA through his first two starts. Milwaukee has a 4.57 team ERA through eight games, though that goes down to 3.77 with Peralta’s innings removed.

Milwaukee enters Saturday night with a 2-7 SU record in its last nine games against the Cardinals. The Brewers still won the NL Central by five games last season despite their recent struggles against St. Louis.

Cardinals vs Brewers Pick & Insights

Cardinals: Keys to Victory

Steven Matz signed a four-year, $44 million contract with the Cardinals during the offseason and is expected to be a reliable left-hander for this team for years to come. St. Louis would love to see their new pitcher bounce back from his ugly debut with a strong start here, leading the Cardinals to a Cardinals vs Brewers prediction win in the process.

Brewers: Keys to Victory

Milwaukee is off to a slow start on offense this season averaging only three runs per game. A high-scoring game doesn’t suit the Brewers well in this matchup, so the best path to being the winning Cardinals vs Brewers pick would be another low-scoring win similar to the 5-1 victory they earned on Thursday.

Odds Shark’s Computer Cardinals vs Brewers Prediction: Cardinals +100

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Shark Bites
  • St. Louis is 5-1 SU in its last 5 road games vs. Milwaukee.
  • Milwaukee is 5-11 SU over its last 16 games.
  • The UNDER is 5-2 in Milwaukee’s last 7 home games.

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