Flag Our Top Sportsbooks
50% BONUS Up To $1000
125% BONUS Up To $2500
50% BONUS Up To $1000
March Madness East Region Odds Are Here!

We’re halfway through the Sweet 16 of the March Madness tournament, and we have an East Region whose top two seeds have been sent home. With Houston the new favorite to be the 2022 national champion, in March Madness East Region odds it is now No. 3 seed Purdue that is the favorite after top-seeded Baylor was knocked out in the Round of 32.

Joe Fortenbaugh has provided his East Region best bet to go along with some great analysis below:

Online sportsbook [ol-sportsbook-bp:48:Bovada:26:Bodog] has released March Madness East Region odds as we move to the second night of Sweet 16 action with the No. 3-ranked Boilermakers the favorites at -125, followed by No. 4 UCLA (+220), No. 8 North Carolina (+400) and No. 15 Saint Peter’s (+2500) to round out the region.

Join A Top NCAAB Sportsbook

With Purdue listed as the favorite in March Madness East Region odds, that means you need to bet $125 on the Boilermakers to win the region to profit $100. Additionally, our sports betting calculator tells us that Purdue’s -125 odds represent an implied win probability of 55.56 percent.

Who Will Win The March Madness East Region?

March Madness East Region Odds
Team Odds
Purdue Boilermakers -125
UCLA Bruins +220
North Carolina Tar Heels  +400
Saint Peter’s Peacocks +2500

Odds as of March 25 at [ol-sportsbook-bp:48:Bovada:26:Bodog]

New to betting on college hoops? Be sure to check out our March Madness betting guide to help get you in the game. Also, keep an eye on our college basketball odds page for the latest up-to-date betting lines. Lastly, if your bracket is busted, no problem, take a look at our Bets over Brackets page to give you some insight on how to continue to enjoy March Madness after your bracket is in shambles.

March Madness East Region Odds: Why Purdue Is The Favorite

In what has been the most entertaining region in the bracket, No. 3 Purdue sits as the top remaining seed as we advance through the Sweet 16. No. 2 Kentucky opened the tournament at the top of the oddsboard but the Wildcats were downed by the Saint Peter’s Peacocks, ending their run early. That upset ranks fourth among the top 10 biggest upsets in March Madness history.

March Madness Betting Sites

Baylor took care of business in the Round of 64, topping Norfolk State 85-49 and covering the 21-point spread. However, the Bears fell short in their Round of 32 matchup with North Carolina, leaving Purdue as the top remaining seed in the region.

The Boilermakers cruised to a 22-point victory against Yale in their Round of 64 matchup. They got past a tough test in Texas and now will have to try to turn the Cinderella Peacocks back into a pumpkin if they want to get to the Elite Eight.

Breaking Down The East Region

No. 3 Purdue is a matchup nightmare for any team. They have a big center in Zach Edey and they have one of the best players in all of college basketball in Jaden Ivey. The Boilermakers took care of Yale 78-56 and were 3.5-point favorites against No. 6 Texas. 

Purdue now faces Saint Peter’s after the Peacocks’ Cinderella story continued with their win over No. 7 Murray State last Saturday.

 Add Another Sportsbook To Your Roster Now  

Fourth-seeded UCLA edged a solid Akron team 57-53 in its opener and beat No. 5 Saint Mary’s 72-56 on Saturday night to advance to the Sweet 16 for the second consecutive year.

The East opened the tournament very top-heavy as the odds indicated, but this is the region that has had several upsets. 

March Madness East Region Historical Information

Only two top seeds have won the East Region over the past 11 years. Of those two winners, North Carolina in 2016 lost in the national final to Villanova, while in 2018 it was Villanova coming out of the East and going on to win its second title in three years.

Here’s a look at the March Madness East Region results since the 2010 season:

March Madness East Region History
Season No. 1 Seed East Region Winner East Region Winner Final Four Result East Region Winner Championship Result
2021 Michigan UCLA (#11) Gonzaga 93, UCLA 90 (OT) (Loss) N/A
2019 Duke  Michigan State (#2) Texas Tech 61, Michigan St. 51 (Loss) N/A
2018 Villanova  Villanova (#1) Villanova 95, Kansas 79 (Win) Villanova 79, Michigan 62 (Win)
2017 Villanova South Carolina (#7) Gonzaga 77, South Carolina 73 (Loss) N/A
2016 North Carolina North Carolina (#1) North Carolina 83, Syracuse 66 (Win) Villanova 77, North Carolina 74 (Loss)
2015 Villanova Michigan State (#7) Duke 81, Michigan St. 61 (Loss) N/A
2014 Virginia UConn (#7) UConn 63, Florida 53 (Win) UConn 60, Kentucky 54 (Win)
2013 Indiana Syracuse (#4) Michigan 61, Syracuse 56 (Loss) N/A
2012 Syracuse Ohio State (#2) Kansas 64, Ohio State 62 (Loss) N/A
2011 Ohio State Kentucky (#4) UConn 56, Kentucky 55 (Loss) N/A
2010 Kentucky West Virginia (#2) Duke 78, West Virginia 57 (Loss) N/A

March Madness East Region Odds FAQ

Where can I bet on the odds to win the East Region for March Madness?

You can find odds for the winner of the East Region of March Madness, and most other college basketball futures, at many popular online sportsbooks. Odds Shark’s experts have compiled and reviewed a list of the best March Madness Betting Sites to help you bettors find the best site to place wagers and be successful.

How should I bet on the East odds for March Madness?

When making futures bets, like wagering on the winner of the East Region, you should consider the chance a team has to win the region, but also their potential value. Odds Shark’s How to Bet on March Madness guide has in-depth strategies and tips on how to successfully bet on the NCAAB Tournament this year.

Who has the best odds to win the East Region for March Madness?

The favorite to make it out of the East Region right now is Purdue. Oddsmakers see the No. 3 Boilermakers as the team most likely to come out of the East side of the bracket during 2022’s March Madness.