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March Madness 2 vs 15 Betting History

In 10 March Madness brackets between 2002 and 2011, no No. 15 seed had upset a No. 2 seed. But since 2012, it has happened on five occasions, throwing fear into bettors and destroying countless brackets.

The most recent happened just last year, as little-known Oral Roberts knocked off No. 2 Ohio State 75-72 as a whopping 16-point underdog.

The 15 seed has gone 56-43-1 ATS against the 2 seed since 1996.

But it was Norfolk State that pulled off the biggest 2 vs 15 upset in modern March Madness betting history, taking out Missouri 86-84 as a 21-point underdog in 2012. On the same day, Lehigh defeated Duke 75-70 as an 11-point underdog. Ironically, it was No. 7 seed Florida that ended Norfolk State’s run in the second round with an 84-50 victory as a 14-point favorite. Lehigh fell to No. 10 seed Xavier 70-58 in the second round as a 4-point underdog.

Only four other times in NCAA Tournament history prior to 2012 had there been an upset with a No. 15 seed defeating a No. 2. Richmond was the first to accomplish the feat in 1991 with a 73-69 victory against Syracuse. Steve Nash’s Santa Clara team did it two years later with a 64-61 win over Arizona and then Coppin State posted the largest margin of victory ever for a No. 15 by routing South Carolina 78-65 in 1997. Four years after that, Hampton took out Iowa State by the smallest margin for a No. 15, 58-57.

See Odds Shark’s Best March Madness Sites

Who Has The Betting Edge In The 2 vs 15 matchup?

Backing the lower seed has been the way to go in the No. 2 vs No. 15 matchup as the No. 15 seed has gone 56-43-1 ATS since 1996. Since 2008, however, spread betting in this matchup has been a virtual coin flip with No. 15 having a minuscule 28-23-1 ATS edge. 

Seed vs Seed Stats: 1 vs 16 | 2 vs 15 | 3 vs 14 | 4 vs 13 | 5 vs 12 | 6 vs 11 | 7 vs 10 | 8 vs 9

#2 Seed vs #15 Seed
#2 Seed Score #15 Seed Score Date ATS Win Win Seed ATS Seed
Houston 87 Cleveland State 56 2021-03-19 Houston 2 2
Ohio State 72 Oral Roberts 75 2021-03-19 Oral Roberts 15 15
Alabama 68 Iona 55 2021-03-20 Iona 2 15
Iowa 86 Grand Canyon 74 2021-03-20 Grand Canyon 2 15
Kentucky 79 Abilene Christian 44 2019-03-21 Kentucky 2 2
Michigan 74 Montana 55 2019-03-21 Michigan 2 2
Tennessee 77 Colgate 70 2019-03-22 Colgate 2 15
Michigan State 76 Bradley 65 2019-03-21 Bradley 2 15
Duke 89 Iona 67 2018-03-15 Duke 2 2
North Carolina 84 Lipscomb 66 2018-03-16 Lipscomb 2 15
Purdue 74 CS Fullerton 48 2018-03-16 Purdue 2 2
Cincinnati 68 Georgia State 53 2018-03-16 Cincinnati 2 2
Duke 87 Troy 65 2017-03-17 Duke 2 2
Louisville 78 Jacksonville State 63 2017-03-17 Jacksonville State 2 15
Arizona 100 North Dakota 82 2017-03-16 PUSH 2 PUSH
Kentucky 79 Northern Kentucky 70 2017-03-17 Northern Kentucky 2 15
Michigan State 81 Middle Tennessee 90 2016-03-18 Middle Tennessee 15 15
Oklahoma 82 CSU Bakersfield 68 2016-03-18 CSU Bakersfield 2 15
Xavier 71 Weber State 53 2016-03-18 Xavier 2 2
Villanova 86 UNC Asheville 56 2016-03-18 Villanova 2 2
Kansas 75 New Mexico State 56 2015-03-20 Kansas 2 2
Arizona 93 Texas Southern 72 2015-03-19 Texas Southern 2 15
Gonzaga 86 North Dakota State 76 2015-03-20 North Dakota State 2 15
Virginia 79 Belmont 67 2015-03-20 Belmont 2 15
Kansas 80 Eastern Kentucky 69 2014-03-21 Eastern Kentucky 2 15
Villanova 73 Wisc-Milwaukee 53 2014-03-20 Villanova 2 2
Michigan 57 Wofford 40 2014-03-20 Michigan 2 2
Wisconsin 75 American 35 2014-03-20 Wisconsin 2 2
Ohio State 95 Iona 70 2013-03-22 Ohio State 2 2
Georgetown 68 Florida Gulf Coast 78 2013-03-22 Florida Gulf Coast 15 15
Miami 78 Pacific 49 2013-03-22 Miami 2 2
Duke 73 Albany 61 2013-03-22 Albany 2 15
Kansas 65 Detroit 50 2012-03-16 Kansas 2 2
Duke 70 Lehigh 75 2012-03-16 Lehigh 15 15
Missouri 84 Norfolk State 86 2012-03-16 Norfolk State 15 15
Ohio State 78 Loyola 59 2012-03-15 Ohio State 2 2
North Carolina 102 Long Island 87 2011-03-18 Long Island 2 15
Notre Dame 69 Akron 56 2011-03-18 Akron 2 15
Florida 79 Santa Barbara 51 2011-03-17 Florida 2 2
San Diego State 68 Northern Colorado 50 2011-03-17 San Diego State 2 2
Ohio State 68 Santa Barbara 51 2010-03-19 Santa Barbara 2 15
West Virginia 77 Morgan State 50 2010-03-19 West Virginia 2 2
Kansas State 82 North Texas 62 2010-03-18 Kansas State 2 2
Villanova 73 Robert Morris 70 2010-03-18 Robert Morris 2 15
Michigan State 77 Robert Morris 62 2009-03-20 Michigan State 2 2
Oklahoma 82 Morgan State 54 2009-03-19 Oklahoma 2 2
Duke 86 Binghamton 62 2009-03-19 Duke 2 2
Memphis 81 CS Northridge 70 2009-03-19 CS Northridge 2 15
Texas 74 Austin Peay 54 2008-03-21 Texas 2 2
Georgetown 66 UMBC 47 2008-03-21 Georgetown 2 2
Tennessee 72 American 57 2008-03-21 American 2 15
Duke 71 Belmont 70 2008-03-20 Belmont 2 15
Wisconsin 76 Texas A&M C.C. 63 2007-03-16 Wisconsin 2 2
Memphis 73 North Texas 58 2007-03-16 North Texas 2 15
UCLA 70 Weber State 42 2007-03-15 UCLA 2 2
Georgetown 80 Belmont 55 2007-03-15 Georgetown 2 2
Texas 60 Pennsylvania 52 2006-03-17 Pennsylvania 2 15
Ohio State 70 Davidson 62 2006-03-17 Davidson 2 15
UCLA 78 Belmont 44 2006-03-16 UCLA 2 2
Tennessee 63 Winthrop 61 2006-03-16 Winthrop 2 15
Connecticut 77 Central Florida 71 2005-03-18 Central Florida 2 15
Oklahoma State 63 Southeastern Louisiana 50 2005-03-18 Southeastern Louisiana 2 15
Wake Forest 70 Chattanooga 54 2005-03-17 Chattanooga 2 15
Kentucky 72 Eastern Kentucky 64 2005-03-17 Eastern Kentucky 2 15
Mississippi State 85 Monmouth 52 2004-03-19 Mississippi State 2 2
Oklahoma State 75 Eastern Washington 56 2004-03-19 Oklahoma State 2 2
Gonzaga 76 Valparaiso 49 2004-03-18 Gonzaga 2 2
Connecticut 70 Vermont 53 2004-03-18 Vermont 2 15
Pittsburgh 87 Wagner 61 2003-03-21 Pittsburgh 2 2
Florida 85 Sam Houston State 55 2003-03-21 Florida 2 2
Wake Forest 76 East Tennessee State 73 2003-03-21 East Tennessee State 2 15
Kansas 64 Utah State 61 2003-03-20 Utah State 2 15
Oklahoma 71 Illinois-Chicago 63 2002-03-15 Illinois-Chicago 2 15
Connecticut 78 Hampton 67 2002-03-15 Hampton 2 15
Oregon 81 Montana 62 2002-03-14 Montana 2 15
Alabama 86 Florida Atlantic 78 2002-03-14 Florida Atlantic 2 15
Arizona 101 Eastern Illinois 76 2001-03-16 Arizona 2 2
North Carolina 70 Princeton 48 2001-03-16 North Carolina 2 2
Kentucky 72 Holy Cross 68 2001-03-15 Holy Cross 2 15
Iowa State 57 Hampton 58 2001-03-15 Hampton 15 15
Temple 73 Lafayette 47 2000-03-17 Temple 2 2
Cincinnati 64 UNC Wilmington 47 2000-03-17 UNC Wilmington 2 15
St. John’s 61 Northern Arizona 56 2000-03-16 Northern Arizona 2 15
Iowa State 88 Cent Conn State 78 2000-03-16 Cent Conn State 2 15
Utah 80 Arkansas State 58 1999-03-12 Utah 2 2
Miami 75 Lafayette 54 1999-03-12 Miami 2 2
Maryland 82 Valparaiso 60 1999-03-11 Maryland 2 2
Stanford 69 Alcorn State 57 1999-03-11 Alcorn State 2 15
Purdue 95 Delaware 56 1998-03-13 Purdue 2 2
Kentucky 82 South Carolina State 67 1998-03-13 South Carolina State 2 15
Cincinnati 65 Northern Arizona 62 1998-03-12 Northern Arizona 2 15
Connecticut 93 Fairleigh Dickinson 85 1998-03-12 Fairleigh Dickinson 2 15
Duke 71 Murray State 68 1997-03-14 Murray State 2 15
Utah 75 Navy 61 1997-03-14 Navy 2 15
South Carolina 65 Coppin State 78 1997-03-14 Coppin State 15 15
UCLA 109 Charleston Southern 75 1997-03-13 UCLA 2 2
Cincinnati 66 UNC Greensboro 61 1996-03-15 UNC Greensboro 2 15
Georgetown 93 Miss Valley State 56 1996-03-15 Georgetown 2 2
Kansas 92 South Carolina State 54 1996-03-15 Kansas 2 2
Wake Forest 64 Northeast Louisiana 50 1996-03-15 Northeast Louisiana 2 15

March Madness 2 vs 15 Betting History FAQ

Where can I bet on the 2 vs 15 seed March Madness game?

Experienced bettors and casual fans looking to bet on the 2 vs 15 seed March Madness game should refer to Odds Shark's Best March Madness Betting Sites Online guide. The guide reviews the top NCAAB tournament sportsbooks and gives insight into the best place to bet on March Madness this year.

How do I bet on the 2 vs 15 seed March Madness game?

There are multiple ways to bet on the 2 vs 15 seed March Madness game, including a moneyline bet, a spread bet, or many different props. Odds Shark's How to Bet on March Madness guide outlines all the bet formats you can utilize during the NCAAB tournament and some general March Madness betting tips for each.

How do I bet on the 2 vs 15 seed March Madness game?

The last time a 15 seed beat a 2 seed in the opening round of March Madness was in 2016, when the Middle Tennessee Blue Raiders beat the Michigan State Spartans, 90-81. Only five 15 seeds have won the matchup since 2000, though two different lower seeds topped the favorite in the 2013 tournament.