The Florida State Seminoles remain at No. 2 in the AP Top 25 for this week, and they'll kick off the Week 10 college football schedule on Thursday night as 6.5-point road favorites on the Sportsbook betting lines at the online sportsbooks against the Louisville Cardinals.
Florida State is 7-0 SU but just 1-6 ATS on the season, and they're 4-8 ATS in their last dozen games as favorites on the road according to the college football betting trends for this week. Louisville will enter Thursday night's game at 6-2 SU and 5-3 ATS on the season, and they're 6-2 ATS in their last eight home games against fellow ACC teams.
There are four games between ranked teams on the college football betting slate for Week 10, and the biggest has No. 7 Ole Miss as a 3-point favorite on the Sportsbook odds against No. 7 Auburn. As well, No. 10 TCU opened as a 5.5-point road favorite against No. 20 West Virginia.
The other two ranked matchups for this week are out in the Pac-12, with No. 25 UCLA Sportsbook as a 5-point home favorite against No. 14 Arizona, and No. 15 Arizona State Sportsbook as a 4.5-point home favorite against No. 18 Utah. No. 5 Oregon opened as an 11.5-point home favorite against unranked Stanford for their matchup on Saturday.
Elsewhere, top-ranked Mississippi State opened as an 11.5-point home favorite against Arkansas, while No. 9 Georgia opened as a 13-point favorite against Florida for their game at EverBank Field, and No. 6 Notre Dame opened as a 15-point favorite on the road against Navy. The Fighting Irish are 4-1 ATS in their last five games against the Midshipmen.
College Football Week 10 Sportsbook Betting Lines at Sportsbook (Posted As Available)
THURSDAY, OCTOBER 30 7:30pm ET - Florida State at Louisville (+6.5) 7:30pm ET - Troy at Georgia Southern (-24)
FRIDAY, OCTOBER 31 8:00pm ET - Cincinnati at Tulane (+3.5) 8:00pm ET - Tulsa at Memphis (-22)
SATURDAY, NOVEMBER 1 11:30pm ET - Air Force at Army (+4) 12:00pm ET - Oklahoma at Iowa State (+15.5) 12:00pm ET - UCF at Connecticut (+11.5) 12:00pm ET - Maryland at Penn State (-3) 12:00pm ET - Northwestern at Iowa (-5.5) 12:00pm ET - East Carolina at Temple (+7.5) 12:00pm ET - Wisconsin at Rutgers () 12:00pm ET - Rice at Florida International (+7) 12:00pm ET - Duke at Pittsburgh (-1) 12:00pm ET - Louisiana-Monroe at Texas A&M (-32) 12:30pm ET - Boston College at Virginia Tech (-5.5) 12:30pm ET - North Carolina at Miami (-12) 1:00pm ET - Washington at Colorado (+5.5) 1:00pm ET - Central Michigan at Eastern Michigan (+16.5) 2:30pm ET - Western Michigan at Miami-Ohio (+6) 3:00pm ET - Western Kentucky at Louisiana Tech (-5) 3:00pm ET - North Carolina State at Syracuse (-5) 3:30pm ET - Purdue at Nebraska (-23.5) 3:30pm ET - TCU at West Virginia (+5.5) 3:30pm ET - Florida vs. Georgia (-13) (EverBank Field) 3:30pm ET - BYU at Middle Tennessee (+7) 3:30pm ET - Indiana at Michigan (-8.5) 3:30pm ET - Virginia at Georgia Tech (-4) 3:30pm ET - Georgia State at Appalachian State (-6.5) 4:00pm ET - Kansas at Baylor (-35) 4:00pm ET - Kentucky at Missouri (-6.5) 4:00pm ET - Texas State at New Mexico State (+8.5) 4:00pm ET - Houston at South Florida (+9.5) 4:30pm ET - USC at Washington State (+7.5) 5:00pm ET - Arkansas State at Idaho () 5:00pm ET - South Alabama at Louisiana-Lafayette (-7) 5:30pm ET - New Mexico at UNLV (-1) 7:00pm ET - Auburn at Ole Miss (-3) 7:00pm ET - Colorado State at San Jose State (+7) 7:00pm ET - Old Dominion at Vanderbilt (-10) 7:00pm ET - UAB at Florida Atlantic () 7:15pm ET - Arkansas at Mississippi State (-11.5) 7:30pm ET - Stanford at Oregon (-11.5) 7:30pm ET - Texas at Texas Tech () 7:30pm ET - Tennessee at South Carolina (-8) 8:00pm ET - Oklahoma State at Kansas State (-13) 8:00pm ET - Notre Dame at Navy (+15) 8:00pm ET - Illinois at Ohio State (-28.5) 8:00pm ET - Southern Miss at UTEP (-5.5) 10:30pm ET - California at Oregon State (-4.5) 10:30pm ET - Arizona at UCLA (-5) 10:30pm ET - San Diego State at Nevada (-5) 10:45pm ET - Wyoming at Fresno State (-11) 11:00pm ET - Utah State at Hawaii (+2) 11:00pm ET - Utah at Arizona State (-4.5)