Chicago White Sox vs Chicago Cubs Betting Pick and Odds Preview

The Chicago White Sox will look to pick up a road win when they take on the Cubs in Chicago at Wrigley Field on Friday in MLB baseball betting odds action.

The match puts starter Carlos Rodon for the Chicago White Sox on the hill facing Kyle Hendricks for the Chicago Cubs. Rodon brings a 3-2 mark to the game, while Hendricks is 4-4 to date on the season.

Prediction-scoring formulas run on this game pick a potential 4.2-2.5 result in favor of the Cubs. View the computer score prediction and who will win the pick on the moneyline for all upcoming MLB matchups here.

Chicago White Sox vs Chicago Cubs Matchup

Team Betting Records & Power Rankings

46-38 Chicago battles the White Sox, currently with a 38-44 mark. Stay Informed: follow us on Twitter for odds specials, betting line moves and Chicago vs Chicago injuries news.

The MLB Power Rankings show a disparity between these teams, with the Chicago Cubs rated this week at No. 10 and the Chicago White Sox sitting at No. 20.

Statistical Matchup

The game also pits Chicago Cubs No. 22-rated offense, averaging 3.94 runs per game, against a Chicago White Sox defense that ranks No. 20 at 4.35 in runs allowed per game. The Chicago Cubs have averaged 8.18 hits per game so far, less than Chicago White Sox batters have averaged on the year (8.24 hits per game).

Chicago owns the No. 6 defense, allowing 3.94 men per game to cross the plate. That contrasts with Chicago's No. 20-rated defense.