Houston Astros vs Oakland Athletics Betting Pick and Odds Preview

The Oakland Athletics look to emerge victorious in MLB odds action as the Houston Astros arrive at O.co Coliseum on Wednesday.

Collin McHugh gets the ball in front of a hostile crowd for the Houston Astros on Wednesday; he's 11-10 on the season. The Oakland Athletics, meanwhile, will counter with Daniel Mengden, who will be looking to improve on his 2-7 mark.

Sportsbook Odds & Computer Pick

The Houston Astros were listed as -138 favorites on the MLB baseball moneyline at many online sportsbooks, including Sportsbook. The total was set at 8.5 before betting started earlier on Wednesday over at Sportsbook.

Prediction-scoring formulas run on this game pick a potential 3.7-3.6 result in favor of the Astros. View the computer score prediction and who will win the pick on the moneyline for all upcoming MLB matchups here.

Houston Astros vs Oakland Athletics Matchup

Team Betting Records & Power Rankings

The Oakland Athletics sport a record of 66-85 heading into this matchup, while the Houston Astros sit at 80-71 on the season Stay Informed: follow us on Twitter for odds specials, betting line moves and Oakland vs Houston injuries news.

The Odds Shark MLB Power Rankings have the Oakland Athletics at No. 13 and the Houston Astros at No. 18 heading into this contest.

Statistical Matchup

When it comes to getting on base, the visiting Houston Astros rank No. 25 at 8.38 hits per game. That compares with the Oakland Athletics No. 24 ranking in that category.

Oakland owns the No. 22 defense, allowing 4.09 men per game to cross the plate. That contrasts with Houston's No. 9-rated defense.