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Mariners vs White Sox Betting & Prediction

The Chicago White Sox (3-1) had the best home record in the American League last season at 53-28, and they’re off to a 1-0 start at home after beating the Seattle Mariners (2-3) on Tuesday night. The White Sox will look to keep things rolling at home as a winning Mariners vs White Sox prediction on Wednesday.

Mariners vs White Sox Betting Preview

Mariners vs White Sox Odds & Analysis

Opening Odds

The White Sox opened as -116 favorites in this matchup and have settled in at Chicago -120 as early Mariners vs White Sox predictions have leaned slightly in Chicago’s favor. Seattle is going off as a +100 road underdog and the total is down to 9 runs after opening at 9.5 runs. The OVER is 4-1 in the Mariners’ last five games against the White Sox.

Get the best Mariners vs White Sox odds and lines available from our recommended sportsbooks for your favorite picks of the night.

  • Best Spread
    -185
    +170
    SEA+1.5
    -1.5CHW
  • Best Moneyline
    +109
    -109
    SEA
    CHW
  • Best Total
    +100
    -110
    Over9
    9Under

Starting Pitchers

Robbie Ray was rock-solid in his Mariners debut against the Minnesota Twins last Friday, allowing only three hits and one earned run across seven innings in a 2-1 Seattle win. Ray earned himself a five-year, $115-million deal this offseason after posting a tidy 2.84 ERA and a 1.04 WHIP with 248 strikeouts in 193.1 innings with the Toronto Blue Jays last season.

Dallas Keuchel is set to make his 2022 debut on Wednesday night. Keuchel was outstanding in 11 starts for the White Sox in 2020 with a 1.99 ERA and a 1.09 WHIP, but those numbers ballooned up to a 5.28 ERA and a 1.53 WHIP across 162 innings last season.

Seattle’s Struggling Offense Has Led To A Rough Start

Seattle won a pair of one-run games against the Minnesota Twins to kick off its season with a 2-0 record. The Mariners have been outscored 17-6 in three games since, with two blowout losses against the Twins and a 3-2 loss to the White Sox on Tuesday.

The front office in Seattle made some significant moves to improve the team this offseason with the signing of Robbie Ray and trades to bring in Jesse Winker and Eugenio Suarez to bolster the offense. Those offensive acquisitions haven’t helped yet – the Mariners are averaging a paltry 2.4 runs per game through their first five games.

Chicago Has Won Three Straight Since Losing Its Season Opener

The White Sox bounced back from a 5-4 loss against the Detroit Tigers on Friday with back-to-back wins of 5-2 and 10-1 over the Tigers. They picked up a third straight win in Tuesday night’s home opener against the Mariners.

Chicago is dealing with a handful of key injuries out of the gate with starting pitchers Lance Lynn and Lucas Giolito, new reliever Joe Kelly and third baseman Yoan Moncada all currently on the injured list. The White Sox have played through those injuries with a 3-1 start, and bettors taking Chicago as their Mariners vs White Sox prediction are hoping that trend continues in this one.

Mariners vs White Sox Pick & Insights

Mariners: Keys To Victory

The Mariners were able to squeak out a 2-1 win in Robbie Ray’s last trip to the mound thanks to a dominant performance from their new ace. With the offense struggling badly early on in 2022, it will be up to Ray again to lead Seattle to victory as a Mariners vs White Sox prediction in this spot.

White Sox: Keys To Victory

It’s too early to tell if Dallas Keuchel’s struggles last season were the signs of a major decline or just the product of an off-year. Either way, Keuchel isn’t likely to outduel the reigning AL Cy Young winner, so Chicago’s offense is going to need to solve Ray and this Mariners bullpen to cash in as a Mariners vs White Sox pick at home.

Odds Shark’s Computer Mariners vs White Sox Prediction: White Sox -120

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Shark Bites
  • Seattle is 2-4 in its last 6 games vs Chicago.
  • Chicago is 6-2 in its last 8 home games.
  • The OVER is 5-2 in Chicago’s last 7 games.

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