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Louisville Cardinals Prediction vs Charlotte 49ers in Week 1 College Football Odds

Charlotte visits Louisville on Thursday, hoping to send the Cardinals to a loss while also covering the spread in college football betting action at Papa John's Cardinal Stadium.

Opening Odds & Computer Pick

Betting fans looking to side with the Louisville Cardinals in this one found them as -39.5-point favorites at Bovada. The over under number was slated to open a short time later.

Handicapping models based on recent betting stats and prediction formulas pick a 48-2 win for the Cardinals. View the computer score prediction and who will win the pick on the moneyline for all upcoming NCAAF matchups here.

Charlotte 49ers vs Louisville Cardinals Matchup

Team Betting Records & Power Rankings

The Louisville Cardinals are 8-5 so far on the season, and 7-6 ATS vs the point spread. The Charlotte 49ers, meanwhile, are 2-10 and 3-6-3 ATS. Those over under betting have seen Louisville go 7-6 and the Charlotte 49ers go 5-7 on the totals. Stay Informed: follow us on Twitter for odds specials, betting line moves and Louisville vs Charlotte injuries news.

According to the Power Rankings here at Odds Shark it's the No. 56-rated Louisville Cardinals and the No. 126-rated Charlotte 49ers in this matchup.

Recent Outings Betting Recap

Charlotte lost its last outing 27-7 against Rice on Saturday, getting a 111-yard receiving performance from Trent Bostick in a losing cause at Rice Stadium.

In their last game, Louisville got a 226-yard performance from Lamar Jackson as a key part of its 27-21 win over Texas A&M.

Next Betting Matchups

Charlotte home to Elon, Saturday, September 10th
Louisville at Syracuse, Friday, September 9th