The Ohio State Buckeyes (5-0 SU, 2-2-1 ATS) are 5-0 SU and ATS in their last five games against the Michigan State Spartans (2-3, 2-3). The Buckeyes will try to continue their dominance over the Spartans with a victory as an Ohio State vs Michigan State prediction favorite this Saturday in East Lansing.

Join A Top-Tier College Football Betting Site Now

Ohio State vs Michigan State Betting Preview

Ohio State vs Michigan State Opening Odds

The Ohio State vs Michigan State odds in this Big Ten showdown didn’t show any movement early in the week after Ohio State opened as a 25.5-point road favorite. The total, meanwhile, opened at 61.5 and did receive enough early betting action on the OVER to climb to 63 points. The UNDER is 6-1 in the last seven games between the Buckeyes and Spartans.

Get the best Ohio State vs Michigan State odds and lines available from our recommended sportsbooks for your favorite picks of the night.

  • Best Spread
  • Best Moneyline
  • Best Total

Ohio State Rolls Into Michigan With Plenty Of Momentum

The Buckeyes cruised to another easy win on Saturday at home against the Rutgers Scarlet Knights, settling for a PUSH as 39-point favorites in a 49-10 victory. Since playing a tight game against the Notre Dame Fighting Irish in a 21-10 season-opening win, Ohio State has averaged 55.8 points per game over its last four games while allowing only 16 points per game over that stretch.

C.J. Stroud was effective in the win over Rutgers, going 13-for-22 with 154 passing yards, two touchdown passes and one interception. But it was Miyan Williams who was the big star of the day on Saturday with 189 rushing yards and five touchdowns on 21 carries. Williams now has 64 carries for 497 yards and eight touchdowns through five games this season.

Michigan State Enters This Matchup With Three Straight Losses

The Spartans kicked off the 2022 season with a pair of wins and covers over the Western Michigan Broncos and Akron Zips. Things have gone south since then, however, as Michigan State is 0-3 SU and ATS over its last three games. Michigan State has been outscored 61-20 over its last two games with disappointing losses to the Minnesota Golden Gophers and Maryland Terrapins.

Payton Thorne went 27-for-44 for 221 passing yards with one touchdown pass in the loss. Thorne has averaged 224.2 passing yards per game this season and will enter this matchup against Ohio State with an 8-to-6 touchdown-to-interception ratio in 2022. The Spartans had a dominant running game last season with Kenneth Walker III leading the way with 6.2 yards per carry, but Jalen Berger and Jarek Broussard haven’t been able to replicate that success this season.

Ohio State: Keys To Victory

Ohio State has won its last four games by an average of 39.8 points per game and beat Michigan State 56-7 when these teams met last year. The usual effort from the Buckeyes should get the job done here as an Ohio State vs Michigan State prediction on the road.

Michigan State: Keys To Victory

The Spartans have allowed 33.3 points per game over their last three games and are about to face one of the most explosive offenses in the country. The team’s only real chance to cover the spread or to try to pull off an upset as an Ohio State vs Michigan State pick will be to have a very good day on offense.

College Football Computer Pick: Ohio State -25.5

Check out more of our signature college football computer picks, plus our favorite sportsbooks that serve football customers. 

Shark Bites
  • Ohio State is 8-1-1 ATS in its last 10 October games.
  • Michigan State is 8-1 SU in its last 9 home games.
  • The UNDER is 5-1 in Michigan State’s last 6 games.
Flag Our Top Sportsbooks
*Terms and Conditions apply to all bonus offers on this website. Please visit operator for details.
Top Pick
125% BONUS Up To $2500
Top Pick
50% BONUS Up To $1000
Top Pick
50% BONUS Up To $1000
Top Pick
50% BONUS Up To $1000
Top Pick
100% BONUS Up To $1000