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Cardinals at 49ers Odds Preview

The San Francisco 49ers’ fall from grace continued in Week 11 in the form of a 29-13 road loss to the arch rival Seattle Seahawks, and things won’t get any easier Sunday when Jim Tomsula’s crew face off against another NFC West divisional foe in the Arizona Cardinals. The Cards showed a lot of guts last week thanks to a big fourth quarter comeback en route to topping the Cincinnati Bengals 34-31 and improving to 8-2 SU on the season.

Shark Bites
  • The 49ers are 7-2-1 ATS in their last 10 games as home underdogs.
  • The total has gone OVER in 9 of the Cardinals' last 11 games.
  • The Cardinals are 7-3 ATS in their last 10 games in November.

Sportsbooks have opened the Cards as hefty 10.5-point favorites for the matchup, which is especially noteworthy. Arizona has only been favored by more than a touchdown on the road four times since 1980.

Arizona has also been one of the hottest OVER teams in the NFL this season, evidenced by the OVER/UNDER going 8-2 in their opening 10 games.

Opening Odds & Computer Pick

Sportsbooks, including Bovada, had set the San Francisco 49ers as 9.5-point underdogs on the opening line for this contest. The total was hovering around 44.5 earlier in the week (check for the current over-under lines at MyBookie).

Odds Shark score prediction models pick a 29-18 result in favor of the Cardinals on Sunday. View the computer score prediction and who will win the pick on the moneyline for all upcoming NFL matchups here.

Arizona Cardinals vs San Francisco 49ers Matchup

Team Betting Records & Power Rankings

The Arizona Cardinals will try to spoil to the party on Sunday; they are 6-4 ATS against the spread this season, while the San Francisco 49ers are 4-6 ATS. Arizona is 8-2 on the over under betting totals; San Francisco is 5-5. Stay Informed: follow us on Twitter for odds specials, betting line moves and San Francisco vs Arizona injuries news.

The power rankings show a disparity between these teams, with the San Francisco 49ers rated this week at No. 32 and the Arizona Cardinals sitting at No. 2.

Statistical Matchup

The game also pits San Francisco's No. 32-ranked offense, averaging 13.9 PPG, against a Cardinals defense that ranks No. 13 this week at 21.6 PPG. The 49ers aerial game is averaging 188.1 yards per game, less than the Cardinals secondary allows through the air, 228.7 YPG per game.

In comparing defenses, the Arizona Cardinals own the league's No. 8-rated front 7 in terms of stopping the run, allowing 92.2 yards per game when on the road. San Francisco, on the other hand, rates No. 18 this week in generating rushing yards at home.

Recent Outings Betting Recap

Arizona comes off a game where it received a 4-TD performance from Carson Palmer in defeating the Bengals 34-31.

The 49ers suffered a Week 11 loss against Seattle in their last game, falling 29-13 at CenturyLink Field.

Betting Trends
  • Arizona is 15-8 ATS in its last 23 games
  • Arizona is 5-1 SU in its last 6 games
  • The total has gone OVER in 9 of Arizona's last 11 games
  • Arizona is 4-1 ATS in its last 5 games on the road
  • San Francisco is 4-12 ATS in its last 16 games
  • San Francisco is 2-7 SU in its last 9 games
  • San Francisco is 4-11 ATS in its last 15 games at home
  • San Francisco is 4-2 SU in its last 6 games at home

Next Betting Matchups

Arizona at St. Louis, Sunday, December 6th
San Francisco at Chicago, Sunday, December 6th