The Packers opened as big 9-point favorites at Sportsbook against the Saints, who have brutal records of 0-3 both SU and ATS through the first three weeks of the season. Green Bay is 1-2 both SU and ATS after falling on Monday to the Seahawks.
NFL bettors might be more inclined to focus on the total when it's released for this matchup, however, as each of the last six games between the Packers and Saints have been OVER results.
Other big Sportsbook lines at Sportsbook this week include the Ravens at -14.5 against the Browns, the Texans at -14 against the Titans, and the Falcons at -8 against the Panthers.
The Lions/Vikings game was off the board early in the week as the sportsbooks await news on Detroit quarterback Matthew Stafford's leg injury.
Week 4 Sportsbook NFL Betting Lines (from Sportsbook)
Thu - Cleveland at Baltimore (-14.5) (8:20pm ET)
Sun - New England at Buffalo (+3.5) (1:00pm ET)
Sun - San Diego at Kansas City (pick) (1:00pm ET)
Sun - Tennessee at Houston (-14) (1:00pm ET)
Sun - Minnesota at Detroit (off) (1:00pm ET)
Sun - Carolina at Atlanta (-8) (1:00pm ET)
Sun - Seattle at St. Louis (+1) (1:00pm ET)
Sun - San Francisco at N.Y. Jets (+4) (1:00pm ET)
Sun - Oakland at Denver (-7) (4:05pm ET)
Sun - Cincinnati at Jacksonville (+1) (4:05pm ET)
Sun - Miami at Arizona (-7) (4:05pm ET)
Sun - Washington at Tampa Bay (-2.5) (4:25pm ET)
Sun - New Orleans at Green Bay (-9) (4:25pm ET)
Sun - N.Y. Giants at Philadelphia (-1) (8:20pm ET)
Mon - Chicago at Dallas (-3.5) (8:30pm ET)
Week 4 NFL Betting Trends and Notes
Cleveland at Baltimore - Matchup Report
The total has gone UNDER in 5 of Cleveland's last 6 games when playing Baltimore
Baltimore is 5-0 SU in its last 5 games at home
San Diego at Kansas City - Matchup Report
The total has gone UNDER in 4 of San Diego's last 5 games when playing Kansas City
The total has gone UNDER in 7 of Kansas City's last 8 games at home
Carolina at Atlanta - Matchup Report
The total has gone OVER in 7 of Carolina's last 10 games
Atlanta is 5-0 SU in its last 5 games at home
San Francisco at NY Jets - Matchup Report
San Francisco is 6-1 SU in their last 7 games when playing NY Jets
The total has gone OVER in 5 of the NY Jets last 6 games at home
New England at Buffalo - Matchup Report
New England is 16-1 SU in its last 17 games when playing Buffalo
The total has gone OVER in 5 of Buffalo's last 6 games
Seattle at St. Louis - Matchup Report
Seattle is 13-1 SU in its last 14 games when playing St. Louis
The total has gone OVER in 4 of St. Louis's last 6 games at home
Minnesota at Detroit - Matchup Report
Minnesota is 16-4 SU in its last 20 games when playing Detroit
The total has gone UNDER in 4 of Detroit's last 5 games when playing at home against Minnesota
Tennessee at Houston - Matchup Report
The total has gone OVER in 4 of Tennessee's last 5 games
Houston is 4-1 SU in its last 5 games
Cincinnati at Jacksonville - Matchup Report
The total has gone OVER in 5 of Cincinnati's last 5 games
Jacksonville is 7-1 SU in its last 8 games when playing at home against Cincinnati
Miami +7 at Arizona -7, Total 40 - Matchup Report
The total has gone UNDER in 7 of Miami's last 9 games on the road
Arizona is 5-0 SU in its last 5 games at home
Oakland at Denver - Matchup Report
The total has gone OVER in 5 of Oakland's last 5 games when playing Denver
The total has gone OVER in 5 of Denver's last 5 games when playing Oakland
New Orleans at Green Bay - Matchup Report
The total has gone OVER in 5 of New Orleans's last 5 games when playing on the road against Green Bay
The total has gone OVER in 5 of Green Bay's last 5 games when playing New Orleans
Washington at Tampa Bay - Matchup Report
The total has gone OVER in 4 of Washington's last 5 games
Tampa Bay is 7-1 SU in its last 8 games when playing at home against Washington
NY Giants at Philadelphia - Matchup Report
NY Giants are 5-0 SU in their last 5 games on the road
Philadelphia is 7-1 SU in their last 8 games when playing NY Giants
Chicago at Dallas - Matchup Report
The total has gone UNDER in 7 of Chicago's last 10 games on the road
The total has gone UNDER in 5 of Dallas's last 5 games