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Israel Adesanya (left) is favored in the Adesanya vs Cannonier (right) odds.

Israel Adesanya will be aiming to remain undefeated at 185 pounds when he defends his UFC middleweight title for the fifth time in a highly anticipated clash with No. 2 contender Jared Cannonier in the main event at UFC 276.

UFC 276 is set to take place on Saturday, July 2, at T-Mobile Arena in Las Vegas and can be seen on PPV. The “Last Stylebender” has opened as a heavy favorite on the Adesanya vs Cannonier odds as he enters his fourth year as UFC middleweight champ.

See UFC odds and other betting markets at BetUS:

Israel Adesanya vs Jared Cannonier Betting Odds

Online sportsbook BetUS has got you covered with all the UFC 276 odds, and has pegged Adesanya as a lofty -340 favorite while Cannonier lags as a distant +260 underdog.

That means backers of the champion must wager $340 to generate potential winnings of $100, while a successful $100 bet on the challenger would pay out $260.

Adesanya vs Cannonier Odds
FighterOdds
Israel Adesanya -340
Jared Cannonier+260

Odds as of May 10 at BetUS

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A deep dive into the Adesanya vs Cannonier betting line using our sports betting calculator shows that Adesanya’s -340 odds translate into a strong implied win probability of 77.27 percent, while Cannonier’s odds reflect an implied win probability of just 27.78 percent.

With two championship clashes on the main card, UFC 276 provides a great opportunity for sports bettors getting into UFC betting action for the first time. So head on over to our How to Bet on UFC guide to learn about UFC betting.

In addition, we have compiled a list of the best UFC betting sites to help you decide where to bet on the UFC. All of your UFC betting news can be found here at Odds Shark.

Adesanya vs Cannonier Odds Analysis

Adesanya has emerged as the darling of the sportsbooks since rising to the top of the UFC middleweight division. The 32-year-old Nigeria native has paid out as a strong favorite in each of his four previous title defenses, sporting average odds of -249 over that stretch.

He also sported short -260 odds in his failed bid for the UFC light heavyweight title last spring at UFC 263.

Cannonier In Familiar Role As Underdog

Facing long odds is nothing new for the “Killa Gorilla.” Cannonier has sported positive odds in four of his past seven outings. He defied the oddsmakers on two occasions over that stretch with wins over Jack Hermansson and David Branch.

That said, he gained plenty of respect in his unanimous-decision loss to Robert Whittaker as a +100 bet at UFC 254, and sported average odds of -150 while claiming victory over Kelvin Gastelum and Derek Brunson in his past two outings.

Adesanya vs Cannonier Betting Preview

Currently perched at No. 3 on the UFC’s pound-for-pound rankings, Adesanya faces high expectations entering his fifth title defense. And with good reason. The Last Stylebender was simply dominant in recent successful title defenses against Marvin Vettori and Paulo Costa.

However, it was a much closer affair when he stepped into the Octagon for a rematch against Robert Whittaker last time out at UFC 271.

Adesanya ultimately earned the decision, and held a clear edge over the No. 1-ranked contender in significant strikes landed. However, he also spent considerable time on the mat for the second time in four middleweight clashes after being taken down on three occasions.

Takedowns are unlikely to be as big a concern against Cannonier, but backers of the Last Stylebender must be concerned about his inability to dominate Whittaker the way he did in their first meeting three years ago.

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Cannonier Has Awesome Punching Power

Cannonier’s versatility has been on full display during his rise up the UFC middleweight rankings. The 38-year-old American is coming off a sensational second-round knockout of Derek Brunson on elbows in his last outing at UFC 271. That marked his fourth TKO victory inside 10 minutes during his current 5-1 run.

There is no questioning the Killa Gorilla’s punching power, particularly considering his ability to quickly change up between orthodox and southpaw stances. He has also proven his ability to defend against both significant strikes and takedown attempts.

Despite facing a three-inch reach disadvantage, Cannonier’s skill set matches up well with Adesanya. However, a lack of experience in championship rounds could work against him in a long drawn-out battle with the champion.

Adesanya vs Cannonier Betting Pick

Adesanya has cemented his position as one of the greatest UFC middleweights of all time during his current reign as champion. However, concerns linger about his lack of killer instinct in his rematch against Whittaker.

Considering Cannonier’s skill set and experience, and long odds, the Killa Gorilla deserves lots of consideration as a value bet ahead of this highly anticipated matchup.

Prediction: Jared Cannonier (+260)