NFL Best Games of 2022 season

Ranking The 5 Most Exciting Games On The 2022 NFL Schedule

The 2022 NFL schedule is out. 

Though we’re still months away from the first snaps of football season, it’s never too early to circle some games on the calendar and think about what side we’re betting on.

Below, we’ll break down five must-watch games on the schedule, ranking our top five best contests in the 2022 NFL season. Some of these games already have early lines out and it’s not too early to lock in a bet over at Sportsbook:


If you like betting on the NFL and want more data and resources, check out our latest 2023 Super Bowl odds and our best NFL betting sites.

NFL’s Most Exciting Games In 2022:

While things will change throughout the season, there are already storylines to watch for next year. Taking into account individual player matchups, the potential importance of games and what the on-field product will be, here are our five most anticipated football games this year:

#5: Week 1: Bills vs Rams

What a way to start the season. Matching up on Thursday night to begin the NFL season on September 8, the Bills will visit the reigning champion Rams for their banner-raising opener.

Beyond it being the season opener and a celebration of Los Angeles’ Super Bowl win, the individual matchups and comparisons are endless. Stefon Diggs vs Cooper Kupp, Josh Allen vs Matt Stafford, and Von Miller’s return to Los Angeles after signing a massive deal in Buffalo this offseason.

With Week 1 lines already out at Sportsbook, this Bills vs Rams opener is slated as a pick’em with both teams at -110. The total is set at OVER/UNDER 52 points.

#4: Week 17: Bills vs Bengals

We’re pumped for the first game of Buffalo’s season, but a late matchup against the Bengals is just as exciting. 

These teams are two of the AFC’s top Super Bowl odds favorites and this late-season contest should have massive playoff seeding implications. With just one first-round bye in the NFL’s new postseason format, this game could very well decide the easiest path to the 2023 Super Bowl.

Look for Bills and Bengals lines throughout the season over at our best NFL betting sites:

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#3: Week 4: Chiefs vs Buccaneers

 A rematch of the 2021 Super Bowl, Patrick Mahomes and Tom Brady are set to meet again in Week 4.

We’ll see what the un-retired Brady looks like and if Patrick Mahomes is still as dominant without Tyreek Hill, but these two teams are title hopefuls. The two QBs have met just twice in recent memory, splitting the meetings before this Week 4 rubber match.

#2: Week 6: Bills vs Chiefs

If this game is anything like the AFC divisional-round meeting between the Bills and Chiefs last season, this has game of the year potential. In that playoff matchup, the teams combined for 28 points in the fourth quarter alone, trading last-second scores into overtime. The Bills had a few opportunities to win the contest but really dropped the ball in the final few possessions. They’ll have a chance for revenge in Kansas City this year.

#1: Week 1: Broncos vs Seahawks 

Kicking off the first Monday Night Football game of the year, we have a fun revenge game. After a massive offseason trade sent QB Russell Wilson from Seattle to Denver, the longtime Seahawks gunslinger will make an immediate return. How will Russ be received? Can he lead his new team to victory?

This one also has early odds out, with the Broncos favored at -4 on the spread. The total is set at OVER/UNDER 41 at Sportsbook.

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How To Bet On Exciting NFL Games:

It’s never too early to bet on these anticipated NFL matchups, with early lines already out at our top NFL betting sites. Find a point spread to wager on and lock in a bet you’ll be happy to cash in a few months.

A spread in football is a figure made by odds specialists that reflects the expected margin of victory or defeat for NFL teams.

The “favorite” team would need to cover the set number of points (denoted by a minus sign) and the “underdog” has to win outright or not lose the game by more than the set number. Typically, the point spread for an NFL game would look like this:

Dallas Cowboys -7
Green Bay Packers +7

This means that the Cowboys are favored to beat the Packers by seven points or more.