OddsShark Top Sportsbooks

*Terms and Conditions apply to all bonus offers on this website. Please visit operator for details.

Slumps Collide as Cardinals Host 49ers in NFC West Matchup

A pair of squads looking to break out of early-season funks square off on Sunday, when the San Francisco 49ers visit the Arizona Cardinals in a clash of NFC West divisional rivals at University of Phoenix Stadium. The Niners are winless SU in four straight contests, while Arizona has failed to cover during its meagre 1-2 start.

Shark Bites
  • The 49ers are 9-3 ATS in their last 12 games on the road against the Cardinals.
  • The Cardinals are 0-5 ATS in their last five games against their division at home.
  • The Cardinals are 9-2 SU in their last 11 games as a favorite of 7.5 or more.

The 49ers have picked up where they left off last season, opening the campaign with three straight losses to fall to 3-20 SU in their past 23, with each of those three victories coming against the Los Angeles Rams. San Francisco is also a dismal 2-17 SU in its past 19 road dates, but is a respectable 3-2-1 ATS over its past six while holding opponents to 23 or fewer points on three occasions.

Arizona has averaged fewer than 19 points per game this season after tallying 34 ppg in its final five games last season. The Cardinals have also struggled with consistency at home, going 5-5-1 SU in their past 11 after winning 16 of their previous 20. Low scoring has been the hallmark of their recent home dates, with the UNDER prevailing in eight of the past 11.

However, the Cardinals have fared well in recent clashes with San Francisco, winning SU in five of six overall and three straight at home, holding the Niners to just 15.7 ppg in those home victories.

Opening Odds & Computer Pick

Oddsmakers at Bovada had the Arizona Cardinals as 6-point favorites in the game, while the betting total was sitting at 45.

Prediction-scoring formulas run on this game picked a potential 26-15 result in favor of the Cardinals. View the computer score prediction and who will win the pick on the moneyline for all upcoming NFL matchups here.

San Francisco 49ers vs Arizona Cardinals Matchup

Team Betting Records & Power Rankings

Arizona will face the 0-3 San Francisco 49ers, who own a 2-1 ATS mark on the season. In totals betting, the Cardinals are 1-2 so far this season while the 49ers are 1-2. Stay Informed: follow us on Twitter for odds specials, betting line moves and Arizona vs San Francisco injuries news.

The Cardinals-49ers odds would favor the Cardinals if the betting lines were set according to power ranks. Arizona is rated No. 21 in our latest OddsShark poll, while the 49ers sit at No. 30.

Statistical Matchup

Offensively, the game matches up the Arizona Cardinals' No. 18-ranked offense (18.67 PPG) against a San Francisco 49ers defense that ranks No. 28 at 25.33 PPG. The Cardinals passing attack has averaged 284.33 yards per game, more than the 49ers give up through the air (214.67 YPG on average).

Defensively, the San Francisco 49ers feature the league's No. 26-rated road run defense, allowing 131 yards per game. The Arizona Cardinals, meanwhile, rank No. 31 in rushing offense at home.

Recent Outings Betting Recap

In their last game, San Francisco's aerial attack generated 332 yards but it was the Rams coming away with a 41-39 victory over San Francisco at Levi's Stadium.

Carson Palmer led the way last time out for the Cardinals, connecting for 325 passing yards, but failing to earn the victory in a 28-17 loss to the Cardinals at University of Phoenix Stadium.

Betting Trends
  • San Francisco is 4-1 ATS in its last 5 games
  • San Francisco is 5-12-1 ATS in its last 18 games
  • San Francisco is 1-17 SU in its last 18 games
  • The total has gone OVER in 4 of San Francisco's last 6 games
  • Arizona is 3-10 ATS in its last 13 games
  • The total has gone OVER in 8 of Arizona's last 10 games
  • Arizona is 1-4 ATS in its last 5 games at home
  • Arizona is 17-7-1 SU in its last 25 games at home

Next Betting Matchups

San Francisco at Indianapolis, Sunday, October 8
Arizona at Philadelphia, Sunday, October 8