The San Francisco 49ers (2-2 SU, 2-2 ATS) are 0-3 SU and ATS in their last three games as a road favorite heading into this Sunday’s matchup against the Carolina Panthers (1-3, 1-3). The 49ers will try to buck this trend with a road win as a 49ers vs Panthers prediction favorite in Carolina.

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49ers vs Panthers Betting Preview

49ers vs Panthers Opening Odds

The 49ers opened as 3-point road favorites before heavy action on them drove the 49ers vs Panthers odds in this matchup all the way up to San Francisco -6.5. The total, meanwhile, has remained steady since opening at 39 points. The UNDER is 7-0 in San Francisco’s last seven games.

Get the best 49ers vs Panthers odds and lines available from our recommended sportsbooks for your favorite picks of the night.

  • Best Spread
    -114
    -105
    SF-5.5
    +6CAR
  • Best Moneyline
    -250
    +220
    SF
    CAR
  • Best Total
    -110
    -110
    Over39.5
    39.5Under

San Francisco’s Dominant Defense Was On Display Monday Night

The Los Angeles Rams were unable to score a touchdown on Monday night as the 49ers cruised to a 24-9 win at home over their division rivals. San Francisco’s defense held the Rams to only 257 total yards in the game and forced two turnovers, including an interception returned for a touchdown in the fourth quarter. The 49ers rank first in the NFL in both total defense, allowing 234.5 yards per game, and scoring defense, allowing 11.5 points per game.

San Francisco improved to 7-2 SU and ATS over its last nine games with Monday’s win. Deebo Samuel made six catches for 115 yards and a touchdown, highlighted by a 57-yard touchdown reception in the second quarter. Jimmy Garoppolo finished the night 16-for-27 with 239 passing yards and that one touchdown pass.

Baker Mayfield And The Panthers Are Struggling Out Of The Gate

Baker Mayfield went 22-for-36 on Sunday with only 197 passing yards, one touchdown pass and two interceptions in Carolina’s 26-16 loss at home to the Arizona Cardinals. The Panthers fell to 1-10 SU and ATS over their last 11 games with the loss and are now 1-8 ATS in their last nine home games as well. Mayfield has averaged only 186.8 passing yards per game this season, but will continue in the starting role until Sam Darnold eventually returns from injured reserve.

On the bright side for Christian McCaffrey’s fantasy football owners and daily fantasy sports players, Mayfield did target McCaffrey nine times in the loss. McCaffrey caught all nine of those passes to record 81 receiving yards and a touchdown. He also added 27 yards on eight rushing attempts in the game.

49ers: Keys to Win

San Francisco has had the NFL’s best defense through the first month of the season, and this group will get a crack at Baker Mayfield and one of the NFL’s worst offenses on Sunday. As long as the 49ers can limit the damage that Christian McCaffrey does, they should be in a good position to win as a 49ers vs Panthers prediction.

Panthers: Keys to Win

Carolina’s offense is averaging only 262.3 total yards and 19.5 points per game. It’s hard to imagine this group scoring much against San Francisco’s stingy defense, so it will be up to the Panthers defense to have a big game and keep this matchup low-scoring to give Carolina a shot at an upset as a 49ers vs Panthers pick at home.

NFL Computer Pick: Panthers +6.5

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Shark Bites
  • San Francisco is 11-5 SU in its last 16 games.
  • Carolina is 14-3 ATS in its last 17 games vs San Francisco.
  • The UNDER is 5-0 in San Francisco’s last 5 road games.
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