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San Francisco Hopes To Continue Road Dominance Vs Giants

San Francisco 49ers vs New York Giants Betting Odds

The San Francisco 49ers went 7-1 SU and 6-2 ATS on the road last season and opened their road schedule this season with a 31-13 win over the New York Jets last week. The 49ers can keep things rolling away from home with a road win over the New York Giants on Sunday afternoon.


San Francisco 49ers vs New York Giants
  • Date/Time: September 27, 1 p.m. ET
  • Stadium: MetLife Stadium
  • TV Coverage: Fox
  • Opening Odds: 49ers -6.5 | O/U 42.5 (Line History)
  • 49ers vs Giants Matchup Report

Opening Odds Analysis

The 49ers opened as 6.5-point favorites in this matchup but have dropped to 4-point favorites after suffering a slew of injuries last Sunday. The total has also dropped from its opener at 42.5 down to its current spot at 41 points. New York is 1-6 ATS in its last seven games at home.

San Francisco News & Notes

With cornerback Richard Sherman already on injured reserve, the 49ers lost two more of their best defensive players in Sunday’s 31-13 win over the Jets as defensive ends Nick Bosa and Solomon Thomas both suffered season-ending torn ACLs. Jimmy Garoppolo and George Kittle are both listed as questionable against the Giants while running back Raheem Mostert is doubtful and Tevin Coleman is out.

The 49ers were one of the best teams in the NFL last season with a 15-4 SU and 11-7-1 ATS record. Their championship window looked wide open after a competitive Super Bowl loss to the Kansas City Chiefs, but this flurry of injuries is going to be difficult to overcome, especially with all three of San Francisco’s division rivals kicking off the season with 2-0 SU records.

New York News & Notes

One week after being held to only six rushing yards on 15 carries, Saquon Barkley was off to a much better start last Sunday against the Chicago Bears with 28 rushing yards on his first four attempts. But disaster struck when the 23-year-old suffered a torn ACL and was lost for the season. The Giants went on to lose 17-13 to the Bears, falling to 2-12 SU over their last 14 games in the process.

This Giants team is built around Barkley. With their star running back out, it’s going to be up to second-year starting quarterback Daniel Jones to carry this team. Jones has completed 63 percent of his passes for 520 passing yards, two passing touchdowns and three interceptions through New York’s first two games.

Betting Pick: UNDER 42.5 points

New York’s offense isn’t likely to come to life in its first week without Saquon Barkley, even against an injury-laden 49ers defense. And with San Francisco also dealing with its share of injuries on offense, this matchup figures to be a low-scoring battle.


Shark Bites
  • San Francisco is 3-7 SU in its last 10 games vs New York.
  • New York is 1-9 SU in its last 10 games vs NFC teams.
  • The UNDER is 2-0 in New York’s first 2 games this season.