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March Madness Best Bets are here!

It’s time for March Madness! The Elite Eight begins today as we inch closer to determining the team that will hoist the 2022 national championship trophy.

With our March Madness best bets, we have everything you need to make educated wagers this year and rake in against your sportsbook, even if your bracket is busted.

Along with the March Madness best bets found below, you can see our college basketball computer picks for even more March Madness picks.

This March Madness best bets page will be updated throughout the 2022 NCAAB tournament to help you handicap your picks. We’ll track our top picks for each day and each round leading up to the national championship game.

March Madness Betting Sites

View the entire March Madness schedule and our college basketball odds page for the latest up-to-date betting lines.

New to betting on college basketball and see some good March Madness bets? Be sure to see our How to Bet on March Madness Games to help you find the best March Madness betting sites and get in on the action.

2022 March Madness Record: 13-12

2022 March Madness Best Bets: Round of 64

The real tournament starts now after the First Four winners secured their spot in the national bracket. I have my best bets for the opening round below.

Michigan vs Colorado State (+1.0)

Matchup Report

There has been a lot of controversy since Sunday regarding whether Michigan should or shouldn’t be in the tournament. Both teams are very good offensively, but Colorado State has looked much better this season, finishing 25-5 compared to Michigan’s 17-14 record. Colorado State’s David Roddy has been lights-out this season; I expect another massive performance in this one.

This is going to be a great battle. The public is favoring Michigan, but the sharps are leaning toward Colorado State. I like Colorado State to get it done in a tight offensive battle.

South Dakota State (+2.0) vs Providence

Matchup Report

Providence comes in after putting up an absolute dud against Creighton in the Big East Tournament. South Dakota State, meanwhile, has won 21 straight games, including a victory over North Dakota State in the Summit League final. South Dakota State had the second-best field-goal percentage and highest three-point percentage in all of college basketball.

Another important note, kenpom.com ranked Providence first in the luck rating category. Despite South Dakota State’s lack of competition in the Summit League, this team can shoot the lights out. I’ve got them upsetting the Friars and moving on.

Memphis vs Boise State UNDER 133.5

Matchup Report

This bet hinges on which team will control the pace of play. Boise State ranks 306th in adjusted tempo and 19th in adjusted defensive efficiency. Memphis plays at a much faster pace but is also a very good defensive team, ranking 33rd in adjusted defensive efficiency. 

Boise State has really turned it up defensively of late, allowing just 52 points to San Diego State and 61 points to Wyoming. I like the Broncos to keep this one low-scoring and remain UNDER this total.

Baylor vs Norfolk State (+21.0)

Matchup Report

Norfolk State may be the 16 seed in this one, but the Spartans have been playing very good basketball in 2022. Since they missed a couple of weeks at the end of December and beginning of January, they have gone 15-2 on their way to winning the MEAC conference. Baylor hasn’t been quite as consistent and will be without guard LJ Cryer for the opening weekend.

A 21-point spread is a lot for a team that will be without one of its best players and is facing a 16th seed with essentially nothing to lose. Baylor should win this game, and quite comfortably, but 21 points is too much.

New Mexico State vs UConn UNDER 131.5

Matchup Report

Points are going to be tough to come by in this one. Kenpom.com ranks Connecticut 36th in adjusted defensive efficiency, while New Mexico State ranks 74th. But more important is the pace that these teams play at. Kenpom.com ranks UConn 292nd in the nation in adjusted tempo, while New Mexico State ranks 223rd.

I believe New Mexico State is going to be able to match up with the Huskies in this one. Both teams are coming off pretty poor offensive performances so there is cause for concern. The UNDER is the play!

Arkansas vs Vermont (+5.5)

Matchup Report

Vermont is an absolute problem – I don’t care what conference they play in. This team can shoot the lights out and is led by a couple of tremendous players in Ryan Davis and Ben Shungu. Vermont ranks tied for fifth in field-goal percentage and takes very good care of the ball, ranking ninth in the country with just 9.7 turnovers a game.

Vermont’s shooting ability as well as its ability to control the ball will be massive. The Catamounts are a popular pick to upset the Razorbacks, and with good reason. I’ll take the points, but it wouldn’t surprise me if they win the game outright.

Murray State (-1.0) vs San Francisco

Matchup Report

Speaking of problems, Murray State is going to be a major problem this tournament. The Racers closed the season with 20 straight wins in the Ohio Valley Conference, and they are led by a name to look for in this tournament, KJ Williams. Williams put up 29 points in the Ohio Valley final and led the team with 18.2 points per game on 54.4 percent shooting from the field.

The Dons, on the other hand, closed out the season with three losses in their last six games. Granted, two of them were to top-seeded Gonzaga, but Murray State is going to be tough to stop with all their offensive firepower. I’ll take the higher-seeded Racers by the small spread.

Virginia Tech vs Texas UNDER 123.5

Matchup Report

Don’t get me wrong, the run that the Hokies had en route to an ACC championship was fun to watch, but they will not have the same success on the offensive end as they did in that tournament. These are two of the slowest-paced teams in the nation as kenpom.com ranks Texas 341st in adjusted tempo and Virginia Tech 344th.

Both teams are very solid on the defensive end, and the pace of play would be beneficial for both teams if it is slow. Despite the low total, I like the UNDER in this game.

Chattanooga (+8) vs Illinois

Matchup Report

Chattanooga does a very good job slowing down the pace of games and controlling the ball. They rank 301st in pace, but rank tied for 42nd in the country in turnovers per game with just 11. Illinois doesn’t play at a fast pace either and isn’t a good free-throw shooting team.

Chattanooga may not win, but this has the feel of a game that could be a lot closer than people think. Chattanooga had seven losses all season and only two of them were by more than eight points. I’ll take the points in this one.

UAB (+8.5) vs Houston

Matchup Report

Houston looked very good to close out the year, winning the AAC comfortably, but the Blazers are very underrated. If they can keep a higher pace in this game, they can make the Cougars very uncomfortable. UAB is a great offensive team, ranked 27th by kenpom.com in adjusted offensive efficiency. They tied for 13th in three-point percentage and tied for 44th in field-goal percentage. 

8.5 points is just too much to give Houston. Jordan Walker is going to be a major point of focus for the Cougars as the UAB guard averaged over 20 points per game this season. I think the Blazers will keep it within reach and cover the 8.5 points. Are you seeing a trend?

TCU (+1.0) vs Seton Hall

Matchup Report

I have been following TCU quite closely this season, and let me tell you, this team causes havoc. The Horned Frogs aren’t a great shooting team, but they can lock you down on the defensive end. According to kenpom.com, they ranked 24th in adjusted defensive efficiency and that is with a strength of schedule rating in the top 10 in the country. Seton Hall’s offense isn’t anything spectacular as the team ranks 76th in adjusted offensive efficiency.

TCU doesn’t have a poor offense, though the Horned Frogs are inconsistent at times. This game has the feel of a really hard-fought low-scoring affair. The slower pace favors the better defensive team, which is the Horned Frogs. I’ll take the Horned Frogs to cover as slight underdogs.

March Madness Betting Sites

2022 March Madness Best Bets: Round of 32

Michigan vs Tennessee (-6.0)

Matchup Report

The Tennessee Volunteers are arguably the hottest team in college basketball, winning eight straight games and facing stiff competition. Most of that competition was tougher than their upcoming matchup with Michigan. Tennessee is also 5-1 SU at a neutral site this season, while Michigan is 2-2. Tennessee has also been very good ATS this season, going 21-13, while Michigan is 14-18.

The Volunteers are a much better overall team. They have a ton of momentum right now and are looking like a team that could make a run at a national championship. This spread will likely only go up, so get it while you can.

Saint Peter’s (+8.0) @ Murray State

Matchup Report

We’re riding with the Cinderella story in the Saint Peter’s Peacocks to cover the spread in this one. That’s something they have become accustomed to doing, covering in eight straight games and nine of their last 10. The Peacocks are 22-9 ATS this season and 4-0 ATS at a neutral site. Despite Murray State’s 30-2 record on the season, they are just 16-13-1 ATS and 2-3 ATS at a neutral site.

The Peacocks defense has been their strong suit all season, but they just scored 85 points against a very good Kentucky team. The Peacocks have an immense amount of momentum heading into this one, winning eight straight games. Give me the points here.

Memphis vs Gonzaga OVER 155

Matchup Report

These are two teams that have tremendous talent on offense and play at an incredibly high pace. According to kenpom.com, Gonzaga is the No. 1 team in adjusted offensive efficiency, while Memphis ranks 46th. The Zags also rank fourth in adjusted tempo, while the Tigers rank 40th. Both teams have solid defenses, but the pace of play in this one should be insanely fast.

I don’t know if the Bulldogs are going to cover as double-digit favorites, but I do believe that both teams are going to score at an alarming rate. The Zags scored 58 points in the second half of their first game. I expect their momentum on the offensive end to carry over.

Houston (-4.5) vs Illinois

Matchup Report

If you watched both of these teams play in the first round, you saw how different their games were. Houston led its contest from wire to wire, while Illinois was ahead for a total of 27 seconds in a 54-53 victory. Houston looked very good as the offense was clicking and the defense picked it up in the second half. Houston is 7-1 ATS at a neutral site this season, while Illinois is a poor 1-4.

Houston should have an answer for Illinois’ Kofi Cockburn. The Cougars are one of the best rebounding teams in the nation, ranking tied for 18th in rebounds per game (36.5) and fourth in offensive rebounds (12.1). Give me the Cougars to win and cover that spread as a lower seed.

Iowa State vs Wisconsin UNDER 125.5

Matchup Report

Two important factors play in our favor for this UNDER to hit. Both of these teams are elite defensively, and they play at a slower pace. According to kenpom.com, Wisconsin ranks 37th in adjusted defensive efficiency, while Iowa State ranks 10th. In regard to pace of play, kenpom.com has the Badgers ranked 221st in adjusted tempo and the Cyclones at 245th. 

Iowa State gave up just 54 points in the opening round, while Wisconsin gave up 60. On the offensive end, these teams aren’t nearly as good. The team that wins this game will be the one that brings its best defensive effort. I’ll take the UNDER.

TCU (+9.0) vs Arizona

Matchup Report

I have been quite high on TCU all season, and the Horned Frogs came out and performed in the opening round, beating Seton Hall 69-42 and holding the Pirates to 29 percent shooting. Arizona looked scary on offense but didn’t defend very well at all in its opener. TCU has been great all year ATS, going 19-11-3, and is 4-3 ATS at a neutral site. Among the Frogs’ last 10 games, they faced Kansas three times, Texas twice, and Baylor and Texas Tech once each. They did quite well ATS in those games, going 5-1-1.

I think that TCU can limit Arizona offensively and keep this one within single digits. TCU has done quite well as an underdog this season, going 9-9, including 5-2 ATS in their last seven as a dog. This spread is way too high – I’ll take the Horned Frogs with the points.

March Madness Betting Sites

2022 March Madness Best Bets: Sweet 16

Arkansas (+9.0) vs Gonzaga

The Gonzaga Bulldogs (the tournament favorites) may have a great record, but that record doesn’t carry over to covering the spread. The Zags are an average 15-15-1 ATS this season, while Arkansas is 20-14-1 ATS. The Razorbacks have thrived in the underdog role, going 4-1 ATS in their last five in that position. Gonzaga has struggled as the favorite, going 1-4 ATS in the last five when giving points.

The Bulldogs have gotten off to slow starts to begin the tournament, and the Razorbacks haven’t played as well as they can to this point. I don’t know if Arkansas is going to be the team to knock off the top-seeded Zags, but I do believe they will keep this one within single digits.

Michigan (+5.0) vs Villanova

The Michigan Wolverines have thrived in the underdog role, going 5-4 as a dog this season and 2-0 in the tournament. On top of that, Michigan is 4-1 ATS in its last five games as an underdog. 

Villanova won its first two games of the tournament by double digits but is running into a Michigan team that has loads of momentum, which is a key ingredient to March success. Villanova has a very good offense, but nothing that Michigan hasn’t seen yet. I expect a tight, hard-fought game that could ultimately come down to the final possession.

Houston (+1.5) vs Arizona

Two of the hottest teams in college basketball face off in the Sweet 16. Both teams have won nine of their last 10, while Arizona has won eight straight. One team plays at an incredibly fast pace while the other plays much slower. Whichever team is able to control the pace of the game should have the edge.

I think Houston has done a much better job at that to this point. Houston won its first two games by double digits while Arizona squeaked out a tough one against TCU in the Round of 32. Houston is 5-0 ATS in its last five games and 8-1 ATS in nine games this season at a neutral site; Arizona is only 3-4 ATS at a neutral site. I’ll take arguably the hottest team in college basketball to pull this one out and advance to the Elite Eight.

Providence vs Kansas (-8.0)

Providence has fared quite well as an underdog this season but runs into a very difficult matchup in the Kansas Jayhawks. The Jayhawks have played their best basketball at a neutral site, going 9-1 SU and 6-4 ATS in 10 games. Providence on the other hand has gone just 4-2 SU and 3-3 ATS.

According to kenpom.com, the Jayhawks rank fifth in adjusted efficiency margin, while the Friars rank 33rd. The Jayhawks have played a much tougher schedule, ranking third in strength of schedule rating, while the Friars rank 60th. 

Kansas will have the two best players on the floor in Ochai Agbaji and Christian Braun. The Friars have had a good run, but I think the Jayhawks win by double digits.

Saint Peter’s (+12.5) vs Purdue

I mean, Saint Peter’s has been red-hot SU and ATS, while Purdue has had a difficult time covering the spread. The Peacocks are 9-0 SU and ATS in their last nine games, while the Boilermakers are 2-7-1 ATS in their last 10.

In all five of Saint Peter’s games at a neutral site this season, they have covered the spread; Purdue has gone 5-4 ATS in nine games at a neutral site. The key in this one will be the Saint Peter’s defense. According to kenpom.com, Saint Peter’s ranks 28th in adjusted defensive efficiency. My biggest concern for them defensively wouldn’t so much be Purdue’s Jaden Ivey, but more so seven-foot-four center Zach Edey. If the Peacocks can contain Edey on the glass and in the paint, they have a very good chance of covering.

I don’t foresee the Peacocks pulling off the upset in this one, but I do believe they can keep it within seven to 10 points.

March Madness Betting Sites

2022 March Madness Best Bets: Elite Eight

Houston (-2.5) vs Villanova

Matchup Report

Both of these teams come into this one red-hot, but Houston has absolutely dominated to this point. Three double-digit victories and a suffocating defense that doesn't give the opposing team any breathing room. The Cougars have won six straight games, and covered the spread in each of those games. The Cougs are 9-1 ATS at a neutral site, while the Wildcats are 5-3. Villanova also hasn't faired well as an underdog this season, going 1-4 SU.

Houston just faced a better offensive team in the Arizona Wildcats and held them to just 60 points.  I expect a similar defensive output in this one with the Cougars coming out on top and advancing to the Final Four.

Arkansas (+4.0) vs Duke

Matchup Report

Arkansas loves their role as underdogs. The Razorbacks are 5-0 ATS in their last five as a dog, and have been playing tremendous basketball even before the tournament began. They are 17-3 SU in their last 20 games including a statement victory over the top-seeded Gonzaga Bulldogs in the Sweet 16. Arkansas held the best shooting team in the nation to just 38 percent shooting from the field, and 24 percent shooting from three.

Duke, on the other hand, hasn't been great ATS going 2-5 in their last seven games. Like the Hogs, the Blue Devils play much better in their role as an underdog. They are 1-5 ATS in their last six games as a favorite. I think that Arkansas has a legit shot to take this one, so i'll take them with the points.

Miami (FL) vs Kansas OVER 147.5

These are two elite offenses, playing at a high-level right now. Miami just put up 70 points on Iowa State, who only gave up 54 and 49 points in their first two games. While Kansas put up 66 against Providence, who only gave up 57 and 51 points in their first two. Kenpom.com has both of these ranked within the top-20 in adjusted offensive efficiency with the Jayhawks ranked sixth, and the Hurricanes ranked 18th.

If that didn't convince you, these teams both play at a fast pace, and shoot the ball at a high percentage. The Jayhawks ranked 63rd in adjusted tempo, while the Hurricanes rank 139th. Both teams finished with the exact same field goal percentage in the regular season at 47.7 percent, ranking 21st in the nation.

Expect a fast pace in this one, and expect a bunch of points. Give me the over!

March Madness Betting Sites

March Madness Best Bets: Final Four

Villanova (+4.5) vs Kansas

Matchup Report

The Final Four begins on Saturday night with the Villanova Wildcats and the Kansas Jayhawks. Although Villanova doesn't play the most entertaining basketball, they play winning basketball. They are tremendous on the defensive end, and have arguably the best coach in the counrty in Jay Wright. Wright's overall record as a head coach is 642-281. Yes, he has won nearly 70 percent of games he has coached.

The winner of this game is likely going to be the team that does a better job at determining the pace of play. According kenpom.com,The Wildcats rank 345th in the nation in adjusted tempo, while the Jayhawks rank 61st. The Wildcats have been able to determine the pace of play in every game thus far, so I have no reason to believe that they won't do it again. I'll take the points in this one, though I do believe Nova has a great shot at winning it.

North Carolina vs Duke (-4.0)

Matchup Report

Now, over to one of the most highly anticipated games in recent memory. The North Carolina Tar Heels and the Duke Blue Devils will meet for the first time in their history in the NCAA March Madness tournament. Duke is going to be highly motivated after losing to this team earlier in March. Duke will also have the best player on the floor Paolo Banchero.

According to kenpom.com, Duke is the No. 1-ranked team in the country in adjusted offensive efficiency. North Carolina has a very good offense as well, but sometimes struggle on the defensive side. The Tar Heels ranked 39th in the nation in adjusted defensive efficiency this season.

The Blue Devils are going to be too much for the Tar Heels in this one. Banchero is a problem, but the Blue Devils have other players who can step up and hit big shots. I think Coach K's run continues and the Duke Blue Devils win and cover the spread to advance to the National Championship game on Monday.

What are the best March Madness Bets?

There are plenty of ways that you can wager on March Madness. You can make a futures bet in which you choose which team is going to win a specific region (East, West, Midwest or South) or you can even place a bet on which team will win the national championship.

If you’re not into betting on an overall winner, then you can place bets on specific games like I do. There are three main options for good March Madness bets: the spread, moneyline and total. Perhaps the most popular is the point spread in which a team must win by a certain number of points provided by the sportsbook to cover the spread. 

Best March Madness Bets: Point Spread

For example, Gonzaga is a 23-point favorite (or -23), which means not only do the Bulldogs have to win but they must win by 24 points or more to cover. Gonzaga’s opponent would be a 23-point underdog (or +23) and could cover its point spread by winning outright or losing by fewer than 23 points.

Best March Madness Bets: Moneyline

If choosing whether a team will win by a given number of points is too difficult, no problem. With a March Madness moneyline bet, you are simply choosing which team will win the game. There will be a favorite, indicated by a minus (-) sign, and an underdog, which will have a plus (+) sign. This type of bet is simple – just pick the team you think will win the game. Betting on an underdog will provide a better payout but is riskier since that team is not expected to win.

Best March Madness Bets: Totals

If you’ve been watching college basketball all season and feel like you know which teams are dynamic offensive squads and which ones are incredibly smothering defensive teams, then totals bets might be right up your alley. This March Madness bet is choosing whether the final combined score of the two teams will go OVER or UNDER a given total provided by the sportsbook. If the total was set at 149.5 points for a Gonzaga-Georgia State contest, for instance, and the Bulldogs won 83-59, the UNDER would hit.

Making your Best March Madness Bet

The foremost advice that can be given when searching out your March Madness best bets is to do plenty of research rather than blindly wagering on a team because you like their logo. There are also picks services that can assist you with March Madness predictions, or you can dive into the numbers yourself.

March Madness Best Bets: Stats & Trends to focus on

There is no official right or wrong way to handicap a game for a perfect March Madness prediction. Some people look at recent betting trends: Gonzaga is 15-13-2 ATS this season, and the total has gone UNDER in 16 of Georgia State’s last 20 games.

For me, I find trends are a good starting point that could give you a direction in looking into the game. Then you can consider head-to-head matchups if they’re available from places such as Odds Shark’s database or team reports that can show you team statistics in various categories and where they rank within the nation.

There is so much sports data now that you can go in plenty of different directions. I recommend keeping a betting journal to track your success and what methods you used to make your March Madness best bets so that you can repeat your process or tweak it depending on how things are going. Most of all, have fun and bet only what you can afford to lose!

March Madness Best Bets FAQ

Who is the favorite to win March Madness?

The favorite to win 2022 March Madness is Gonzaga. The Bulldogs have been dominant again this season, coming off a near-undefeated season last year. While there's still some time to go before Gonzaga has a chance to avenge their 2021 finals loss, they are currently the favorite to win the National Championship.

How do I make bets on the college basketball tournament now that my March Madness bracket exploded?

We've come up with a comprehensive NCAA tournament betting guide that shows you how to bet on March Madness even after your bracket has exploded. College basketball bettors will learn how to read college basketball odds, the type of wagers they can make on the tournament, and how to make those NCAAB bets.

Where can I bet on March Madness games?

If you want to know where you can bet on March Madness games, you’ll want to look over our list of the best sportsbooks for betting on March Madness. Every March Madness betting site has odds on each and every game. These really are the best places to bet on March Madness matchups.