The Bills are favored in their Thanksgiving game vs the Lions

NFL Thanksgiving: Lions, Giants, Vikings Among Best Bets

It’s time for the annual tradition of shoving food in our faces, ignoring our families and betting on Thanksgiving NFL football.

The NFL will host a tripleheader of gridiron action in Week 12. Here’s a look at what’s on tap to kick off Thursday:

Buffalo Bills (-10.0) at Detroit Lions

New York Giants at Dallas Cowboys (-9.5) 

New England Patriots at Minnesota Vikings (-3.0)

We’re taking a look at some lines and totals from Sportsbook for this Turkey Day slate, but be sure to check out some Thanksgiving football prop bets and Thanksgiving football betting trends as well. 


NFL Thanksgiving Picks: Game Lines

All NFL odds come courtesy of Sportsbook.

Bills at Lions

Thursday, November 24 @ 11:30 a.M. ET
Buffalo Bills-10.0 (-105)-450O 54.0 (-110)
Detroit Lions+10.0 (-115)+335U 54.0 (-110)

Pick: Lions +10.0 (-115)

Detroit has covered the spread in three consecutive games, so we’re counting on them to do the same Thursday.

The Bills, who will now play back-to-back games at Ford Field, just haven’t been as crisp lately. In Week 11 vs the Browns, quarterback Josh Allen had a hard time finding chunk plays through the air and finished with a season-low 197 passing yards. A late-game surge from Cleveland also pushed the Browns within a half-point of covering. 

The Lions are sneaky, and with Buffalo 1-3 ATS in its last four, we like Detroit at +10.0.

Check out our full Lions vs Bills odds and preview here

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Giants at Cowboys

Thursday, November 24 @ 3:30 P.M. ET
New York Giants+9.5 (-110)+325O 44.5 (-110)
Dallas Cowboys-9.5 (-110)-435U 44.5 (-110)

Pick: Giants +9.5 (-110)

After a clunker of a performance at home vs Detroit last week, the Giants enter Thursday hovering around a 9.5-point underdog mark, which would be the G-Men’s steepest line of the season. New York deserves a narrower line, so we recommend wagering on the visiting Giants.

Not only has New York gone 3-1 ATS on the road this season, but the Giants are meeting a Cowboys squad that has lost three straight Thanksgiving Day games. Dallas was favored in each of the last three Turkey Bowls and lost all three straight up. 

The ’Boys are coming off a beatdown win over the Vikings, which might get fans’ hopes up. We see it as a letdown game waiting to happen.

Read our full Giants vs Cowboys preview here.

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Patriots at Vikings

Thursday, November 24 @ 7:20 p.M. ET
New England Patriots+3.0 (-115)+130O 42.0 (-110)
Minnesota Vikings-3.0 (-105)-150U 42.0 (-110)

Pick: Vikings -3.0 (-105)

Don’t let recency bias cloud your judgment here. Minnesota is the better team.

The Vikings were destroyed by the Cowboys a week ago in a game that saw QB Kirk Cousins running for his life. The offensive line has been a disappointment lately and will need to step it up against an excellent Patriots front seven. That’s likely where the game will be decided.

New England’s offense has been stale this year, averaging just 21.9 points per game. Minnesota has way more offensive firepower and should be able to take care of business at home Thursday evening. 

Our full Vikings vs Patriots preview is available here.

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