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George Kittle leads our TNF Prop bets picks

The 2021 NFL season continues into Week 16 with the latest edition of Thursday Night Football. Tonight’s TNF contest features a match between the San Francisco 49ers and Tennessee Titans, two teams jockeying for a spot in the playoffs. Thursday’s contest comes with some great Thursday Night Football prop bets, too.

Online sportsbook Bovada has the 49ers as 3-point road favorites and the total settling in at 44.0 points. For a look at all the lines for this week’s slate of games, check out our NFL odds page for the latest up-to-date information.

Odds Shark also has a preview for this game. For more great football betting content, head over to our NFL page. New to betting on football? Check out our detailed NFL betting guide to help you get in the action.

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In the below tables, we break down the wide selection of Thursday Night Football prop bets, including player props, score props and even special teams prop bets. Come back each week for updated TNF prop bets before every NFL prime-time matchup, as well as our favorite TNF prop bet of the week.

Odds Shark’s Top Week 16 TNF Prop Bet: George Kittle Receiving Yards

For most tight ends, 72.5 receiving yards is a high mark to hit. But not for 49ers TE George Kittle, especially given how he’s playing lately. In the month of December (three games), Kittle has 425 receiving yards, averaging 142 per game, and has broken this line of 72.5 yards in every game. He has 33 targets in his last three games and is clearly the main passing weapon in this San Francisco attack.

The Pick: Kittle OVER 72.5 Receiving Yards

TNF Prop Bet #2: Ryan Tannehill Interception

Ryan Tannehill continues to struggle to keep the football in 2021. He has thrown an interception in seven of his last nine games and has tossed six picks in his last four contests.

The 49ers are not a great ball-hawking team, with just six interceptions on the season, but that’s probably why this line is such good value. I’ll bet on San Francisco’s defense running into a bad throw and Tannehill keeping his pick-happy ways going.

The Pick: Tannehill OVER .5 Interceptions -125


All Week 16 TNF Prop Bets:

First Touchdown Scorer

Player Odds
Jeff Wilson Jr. +600
D’Onta Foreman +1000
Deebo Samuel +650
George Kittle +750
Brandon Aiyuk +1100
AJ Brown +1000
Dontrell Hilliard +1400
Nick Westbrook-Ikhine +1400
Ryan Tannehill +1600
Jauan Jennings +1800
Jeremy McNichols +2200
Chester Rogers +2200

Odds as of December 23 at Bovada

Anytime Touchdown Scorer

Player Odds
Jeff Wilson Jr. -110
D’Onta Foreman +175
Deebo Samuel EVEN
George Kittle +115
Brandon Aiyuk +200
AJ Brown +160
Dontrell Hilliard +275
Nick Westbrook-Ikhine +325
Ryan Tannehill +333
Jauan Jennings +350
Jeremy McNichols +475
Chester Rogers +475

Odds as of December 23 at Bovada

TNF Prop Bets: Yardage

Passing Yards Props

Player OVER/UNDER
Jimmy Garoppolo 245.5
Ryan Tannehill 217.5

Odds as of December 23 at Bovada

Rushing Yards Props

Player OVER/UNDER
D’Onta Foreman 50.5
Deebo Samuel 30.5
Dontrell Hilliard 23.5
Jeff Wilson Jr.  65.5

Odds as of December 23 at Bovada

Receiving Yards Props

Player OVER/UNDER
Brandon Aiyuk 48.5
Deebo Samuel 47.5
George Kittle 72.5
Jauan Jennings 20.5
Jeff Wilson Jr. 7.5
Kyle Juszczyk 8.5

Odds as of December 23 at Bovada

Game Props

Longest Touchdown Scored In The Game

Option Odds
OVER 43.5 Yards -115
UNDER 43.5 Yards -115

Odds as of December 23 at Bovada

Will The Team That Scores First Win The Game?

Option Odds
Yes -190
No +145

Odds as of December 23 at Bovada

Will The Game Go To Overtime?

Option Odds
Yes +850
No -2500

Odds as of December 23 at Bovada

The First Turnover Of The Game Will Be

Option Odds
Fumble +155
Interception -170
No Turnovers In The Game +900

Odds as of December 23 at Bovada

Team To Call The First Timeout Of The Game

Team Odds
Titans -120
49ers -120

Odds as of December 23 at Bovada

Team To Get The First Penalty Of The Game

Team Odds
Titans -120
49ers -120

Odds as of December 23 at Bovada

Score Props

First Score Of The Game - Exact Outcome

Team Odds
Titans TD +220
49ers TD +175
Titans FG +350
49ers FG +330

Odds as of December 23 at Bovada

Margin Of Victory

Outcome Odds
Titans by 1-6 points +375
Titans  by 7-12 points +650
Titans  by 13-18 points +1000
Titans by 19-24 points +2000
Titans by 25-30 points +3500
Titans by 31-36 points +5500
Titans by 37-42 points +8000
49ers by 1-6 points +330
49ers by 7-12 points +475
49ers by 13-18 points +650
49ers by 19-24 points +1000
49ers by 25-30 points +1800
49ers by 31-36 points +3000
49ers by 37-42 points +5000
Tie +5500

Odds as of December 23 at Bovada

Odd/Even Total Points

Option Odds
EVEN -105
ODD -125

Odds as of December 23 at Bovada

TNF Prop Bets: Field Goals

Total Successful Field Goals

Option Odds
0 +2000
1 +600
2 +330
3 +260
4 +330
5 +500
6+ +550

Odds as of December 23 at Bovada


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How To Place A Thursday Night Football Prop Bet:

A prop bet, short for proposition bet, is a bet on any contest or match event that does not directly impact the final score. You can place a bet on a point spread, total or straight-up winner, but props are a good way to stay engaged regardless of the score. NFL prop bets and TNF props are also great ways to take advantage of your research or roster moves that may impact carries or targets on any given week.

You can place one of these many TNF prop bets at any of our recommended NFL betting sites. 

How To Read TNF Prop Bets:

Reading prop bet odds is just like reading any futures odds. If you were to look at fictional NFL First Touchdown Scorer odds for a Cowboys vs Buccaneers game, the odds would look like:

Amari Cooper +300
Tom Brady +450
Rob Gronkowski +700
CeeDee Lamb +1000

If you believe that Cooper is going to score the first TD from these TNF prop odds, and you wagered $40 on him, a winning bet would give you a payout of $160 – your original $40 is returned along with your prize of $120. To find out how much you would make for any bet, consult our Odds Calculator.